DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and FZR1

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	XP_016882352.1	Gene:	FZR1 / 51343	HGNCID:	24824	Length:	528	Species:	Homo sapiens

Alignment Length:	501	Identity:	230/501 - (45%)
Similarity:	320/501 - (63%)	Gaps:	62/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EYQQRLLPGVAVGKKEDIDL-----------------------RCIPTRAGNHWNRNF--VN--- 41
            :|::|||..:.:..:..:..                       |.||:|||.:|:.||  :|
Human    36 DYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENE 100

  Fly    42 -APGDS---------NVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQTDDFRDRHNR---- 92
             :|..:         |..:...||.||:||.|...|..:::        .||:|.|.:.:.
Human   101 KSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQD--------PQTEDRRLQPSTPEKK 157

  Fly    93 ---IFGFASGSSSPVR----TPF--ANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYL 148
               .:..::..|||..    :|:  :.:|..||:||...::|.|::.:.|:|:||||||||||||
Human   158 GLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYL 222

  Fly   149 NLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTI 213
            ||:||||.|.|:||||..||||||.:.|||||||.:.|.:.:|:|.|...|..||:||..|:|.|
Human   223 NLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQI 287

  Fly   214 WDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQ 278
            |||...|:::.||.|:|||.||||...:|:||||||.|||||||.||....|.|:||:.|||||:
Human   288 WDAAAGKKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLK 352

  Fly   279 WSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFW 343
            ||..::.|||||:||:||||......|:..:.||.|.|||:.||||:.||||||||:||||:|||
Human   353 WSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 417

  Fly   344 NVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLS 408
            |.|||:.::||:||:|:.||||::.:.|||:|||::|.|::.|:||||.|:|:|:||:.|||:|:
Human   418 NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA 482

  Fly   409 VSPDNESIVTGGADETLRFWTVFTKQKISK---EPNSVLRLFKGIR 451
            :|||.|:||||..|||||||.||:|.:.:|   |..|||.||..||
Human   483 MSPDGEAIVTGAGDETLRFWNVFSKTRSTKVKWESVSVLNLFTRIR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	194/346 (56%)
		WD40 repeat	149..185	CDD:293791	25/35 (71%)
		WD40	190..446	CDD:295369	147/258 (57%)
		WD40 repeat	190..227	CDD:293791	16/36 (44%)
		WD40 repeat	233..269	CDD:293791	22/35 (63%)
		WD40 repeat	274..310	CDD:293791	18/35 (51%)
		WD40 repeat	317..355	CDD:293791	26/37 (70%)
		WD40 repeat	360..398	CDD:293791	19/37 (51%)
		WD40 repeat	404..436	CDD:293791	21/31 (68%)
FZR1	XP_016882352.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1507
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.890