DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and fzr

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_524852.2	Gene:	fzr / 45922	FlyBaseID:	FBgn0262699	Length:	478	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	237/486 - (48%)
Similarity:	314/486 - (64%)	Gaps:	43/486 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFQSEYQQRLLPGVAVGKKE------------DIDLRCIPTRAGNHWNRNFV-------NAPGDS 46
            ||..||::|:|...:...:.            .:| |.||.||.|:|..||.       |:|..|
  Fly     1 MFSPEYEKRILKHYSPVARNLFNNFESSTTPTSLD-RFIPCRAYNNWQTNFASINKSNDNSPQTS 64

  Fly    47 --------NVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQTDDFRDRHNRIFGFASGSSSP 103
                    ...:|..|||||:||.|...|..::...:....:|.|...:   ..:|.:    .||
  Fly    65 KKQRDCGETARDSLAYSCLLKNELLGSAIDDVKTAGEERNENAYTPAAK---RSLFKY----QSP 122

  Fly   104 VRTPF--------ANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYLNLIDWSSKNTLA 160
            .:..:        :.:|..||:||...::..|::.|.|:|:||||||||||||||:||||:|.||
  Fly   123 TKQDYNGECPYSLSPVSAKSQKLLRSPRKATRKISRIPFKVLDAPELQDDFYLNLVDWSSQNVLA 187

  Fly   161 VGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRL 225
            ||||..||||||.:.|||||||.:.:.|.:|:|||:..|..||:||..||||:||....||||:|
  Fly   188 VGLGSCVYLWSACTSQVTRLCDLSPDANTVTSVSWNERGNTVAVGTHHGYVTVWDVAANKQINKL 252

  Fly   226 EEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQWSPSNRYLASGG 290
            ..|||||.||||..:.|:||||||.|:|||.|.|.....|.|.||:.|||||:|||.|:||||||
  Fly   253 NGHSARVGALAWNSDILSSGSRDRWIIQRDTRTPQLQSERRLAGHRQEVCGLKWSPDNQYLASGG 317

  Fly   291 SDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCIN 355
            :||||.||......|:.::.||.|.|||:.||||..||||||||:||||:||||.|||:.::|::
  Fly   318 NDNRLYVWNQHSVNPVQSYTEHMAAVKAIAWSPHHHGLLASGGGTADRCIRFWNTLTGQPMQCVD 382

  Fly   356 TGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGG 420
            ||:|:.||||::.|.|||:|||::|.|::.|:||||.|:|:|:||:.|||:|::|||.|:||||.
  Fly   383 TGSQVCNLAWSKHSSELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLALSPDGEAIVTGA 447

  Fly   421 ADETLRFWTVFTKQKISKEPNSVLRLFKGIR 451
            .|||||||.||:|.:..||..|||.||..||
  Fly   448 GDETLRFWNVFSKARSQKENKSVLNLFANIR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	196/345 (57%)
		WD40 repeat	149..185	CDD:293791	26/35 (74%)
		WD40	190..446	CDD:295369	151/255 (59%)
		WD40 repeat	190..227	CDD:293791	20/36 (56%)
		WD40 repeat	233..269	CDD:293791	19/35 (54%)
		WD40 repeat	274..310	CDD:293791	21/35 (60%)
		WD40 repeat	317..355	CDD:293791	26/37 (70%)
		WD40 repeat	360..398	CDD:293791	20/37 (54%)
		WD40 repeat	404..436	CDD:293791	21/31 (68%)
fzr	NP_524852.2	WD40	<174..469	CDD:225201	177/294 (60%)
		WD40	178..456	CDD:238121	167/277 (60%)
		WD40 repeat	217..254	CDD:293791	20/36 (56%)
		WD40 repeat	260..296	CDD:293791	19/35 (54%)
		WD40 repeat	301..337	CDD:293791	21/35 (60%)
		WD40 repeat	344..382	CDD:293791	26/37 (70%)
		WD40 repeat	387..425	CDD:293791	20/37 (54%)
		WD40 repeat	431..457	CDD:293791	18/25 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470609
Domainoid	1	1.000	99	1.000	Domainoid score	I1832
eggNOG	1	0.900	-	-		E2759_KOG0305
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I397
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		otm46557
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1507
	10	9.900