DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and cdc20

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_998245.2	Gene:	cdc20 / 406353	ZFINID:	ZDB-GENE-040426-2044	Length:	496	Species:	Danio rerio

Alignment Length:	343	Identity:	144/343 - (41%)
Similarity:	209/343 - (60%)	Gaps:	18/343 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SPVRTPFANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYLNLIDWSSKNTLAVGLGCS 166
            |.|.||   :|....|.:|.:          |.:|||||::::||||||:||..:|.|||||...
Zfish   155 SQVPTP---VSVKKSRYISSY----------PERILDAPDIRNDFYLNLMDWGRQNVLAVGLANQ 206

  Fly   167 VYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRLEEHSAR 231
            ||||.|..|.:..|....:::..|.:|||..:|..:||||....|.:||.:.||::..::.||||
Zfish   207 VYLWDAGEGDIVLLKKMEDDNEYICSVSWSKDGNFLAIGTSDCKVELWDVQYQKRLRSMDGHSAR 271

  Fly   232 VTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQWSPSNRYLASGGSDNRLL 296
            |..|:|..:.|:||||...|.|.|:|....||. ...||..|||||.|||..|||||||:||.:.
Zfish   272 VGCLSWNDHILSSGSRSGLIHQHDVRVADHHIF-TFGGHTQEVCGLTWSPDGRYLASGGNDNMVY 335

  Fly   297 VW---TDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCINTGA 358
            :|   |....:.|:|..||:..||||.|.|.:..:||||||::||.:|.||..:|..:..::|.:
Zfish   336 IWPMTTGSENQAIHALSEHQGAVKALAWCPWQPNILASGGGTSDRHIRIWNASSGSCISSLDTCS 400

  Fly   359 QISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNESIVTGGADE 423
            |:|:|.:|.:.:|||:.||.|..:|:.|:|||..::....||..|:|:|::|||..::.:..|||
Zfish   401 QVSSLVFAPNYKELVSGHGFAHDKVVIWKYPSFAKVTEHEGHEARILNLALSPDGSTLASIAADE 465

  Fly   424 TLRFWTVFTKQK-ISKEP 440
            |:|.|..|.|:| .:|:|
Zfish   466 TIRLWKCFEKEKDAAKKP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	142/340 (42%)
		WD40 repeat	149..185	CDD:293791	17/35 (49%)
		WD40	190..446	CDD:295369	110/255 (43%)
		WD40 repeat	190..227	CDD:293791	14/36 (39%)
		WD40 repeat	233..269	CDD:293791	13/35 (37%)
		WD40 repeat	274..310	CDD:293791	20/38 (53%)
		WD40 repeat	317..355	CDD:293791	17/37 (46%)
		WD40 repeat	360..398	CDD:293791	14/37 (38%)
		WD40 repeat	404..436	CDD:293791	14/32 (44%)
cdc20	NP_998245.2	WD40	<194..484	CDD:225201	123/291 (42%)
		WD40	196..471	CDD:238121	117/275 (43%)
		WD40 repeat	230..267	CDD:293791	14/36 (39%)
		WD40 repeat	273..308	CDD:293791	13/35 (37%)
		WD40 repeat	313..352	CDD:293791	20/38 (53%)
		WD40 repeat	359..397	CDD:293791	17/37 (46%)
		WD40 repeat	402..440	CDD:293791	14/37 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.930