DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fzr2 and cdc20

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_988945.1	Gene:	cdc20 / 394542	XenbaseID:	XB-GENE-970663	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	443	Identity:	165/443 - (37%)
Similarity:	248/443 - (55%)	Gaps:	41/443 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PTRAGNHWNRNFVNAPGDSNVYESSVYSCLL--RNEFLDENITSLENCEQTAQVHAQTDDFRDRH 90
            |:|||..   .|:  |..| ..:..|.|.||  .||..|.:.|..|..:..|.
Frog    80 PSRAGGD---RFI--PNRS-AMQMDVASFLLCKENEPADTSPTKKEQQKAWAM------------ 126

  Fly    91 NRIFGFASGSSSPVR---TPFANISESSQRLLSIF----------KRPMRRLPRRPYKILDAPEL 142
             .:.||....:..:|   .| .|..|..|..|.:.          |:..|.:|..|.::||||::
Frog   127 -NLNGFDMEEAKILRLGGRP-QNAPEGYQNNLKVLYSQKTTPGSSKKTGRYIPSMPDRVLDAPDI 189

  Fly   143 QDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQ 207
            ::|:|||||||||:|.|||.|..|||||:..:|.:..|....:.:..|::|||..||..:|:||.
Frog   190 RNDYYLNLIDWSSQNFLAVALNDSVYLWNYATGDIILLLQMEHSEEYISSVSWIKEGNYLAVGTS 254

  Fly   208 SGYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKL 272
            :..|.:||.:.||::..:..||:||.||:|..:.|:||||...|...|:|....|:: .|.||..
Frog   255 NSEVQLWDVQQQKRLRNMTSHSSRVGALSWNNHILSSGSRTGHIHHHDVRVAQHHVS-TLTGHTQ 318

  Fly   273 EVCGLQWSPSNRYLASGGSDNRLLVW---TDDWPE--PIYAFDEHKAVVKALGWSPHKSGLLASG 332
            |||||:|||..||||||.:||.:.||   ..|..|  |:..|.:|:..|||:.|.|.:|.:||:|
Frog   319 EVCGLKWSPDGRYLASGANDNLVNVWPCVQGDSGEFSPVQTFTQHQGAVKAVAWCPWQSNVLATG 383

  Fly   333 GGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARL 397
            ||::||.:|.|||.:|..:..::|.:|:.::.|:.:.:||::.||.||.|::.|:||::.::..|
Frog   384 GGTSDRHIRIWNVCSGTCLNSVDTHSQVCSILWSTNYKELISGHGFAQNQLVLWKYPTMTRVTEL 448

  Fly   398 SGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKISKEPNSVLRLFKGI 450
            .|||.|||:|::|||..::.:..||||||.|..|....::|:.....|..|.|
Frog   449 KGHTARVLNLAISPDGCTVASAAADETLRLWKCFEVDPVTKKEKEKARSSKSI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	142/355 (40%)
		WD40 repeat	149..185	CDD:293791	19/35 (54%)
		WD40	190..446	CDD:295369	107/260 (41%)
		WD40 repeat	190..227	CDD:293791	14/36 (39%)
		WD40 repeat	233..269	CDD:293791	13/35 (37%)
		WD40 repeat	274..310	CDD:293791	20/40 (50%)
		WD40 repeat	317..355	CDD:293791	17/37 (46%)
		WD40 repeat	360..398	CDD:293791	11/37 (30%)
		WD40 repeat	404..436	CDD:293791	14/31 (45%)
cdc20	NP_988945.1	WD40	198..480	CDD:238121	121/282 (43%)
		WD40 repeat	237..272	CDD:293791	14/34 (41%)
		WD40 repeat	278..315	CDD:293791	15/37 (41%)
		WD40 repeat	320..361	CDD:293791	20/40 (50%)
		WD40 repeat	368..406	CDD:293791	17/37 (46%)
		WD40 repeat	411..449	CDD:293791	11/37 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010