Protein Alignment fzr2 and fzr1a

DIOPT Version :10

• Sequence 1: NP_611854.1
• Gene: fzr2 / 37808
• FlyBaseID: FBgn0034937
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_956547.1
• Gene: fzr1a / 393223
• ZFINID: ZDB-GENE-040426-712
• Length: 495
• Species: Danio rerio
• Alignment Length: 503
• Identity: 235/503 - (46%)
• Similarity: 317/503 - (63%)
• Gaps: 67/503 - (13%)

  Fly     5 EYQQRLLPGVAVG-------KKEDIDL------------------RCIPTRAGNHWNRNF--VN- 41
            :|::|||..:.|.       |.:|:..                  |.||:|||.:|:.||  :|
Zfish     4 DYERRLLRQINVQNDNTSPMKAKDVICHLTPTPESPLSSPSKHGDRFIPSRAGANWSINFHRINE 68

  Fly    42 -------------APGDSNVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQTDDFR------ 87
                         |..||...:...||.||:||.|...|..:        :..||:|.|
Zfish    69 NEKSPSQNKKTKDATSDSGKADGLAYSALLKNELLGAGIEKV--------LDPQTEDRRLQPSTP 125

  Fly    88 DRHNRIFGFASGSSSPVRTPFAN---------ISESSQRLLSIFKRPMRRLPRRPYKILDAPELQ 143
            :|.:.   |:...|:...||..|         :|..||:||...::|.|::.:.|:|:|||||||
Zfish   126 ERRSL---FSYSLSAKRSTPDDNSVSPYSLSPVSSKSQKLLRSPRKPTRKISKIPFKVLDAPELQ 187

  Fly   144 DDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQS 208
            |||||||:||||.|.|:||||..||||||.:.|||||||.:.|.:.:|:|.|...|..||:||..
Zfish   188 DDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHK 252

  Fly   209 GYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLE 273
            |:|.||||...|::..||.|:|||.||||..::|:||||||.|||||||.||....|.|:||:.|
Zfish   253 GFVQIWDATAGKKLFALEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQE 317

  Fly   274 VCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADR 338
            ||||:||..::.|||||:||:||||......|:..:.||.|.|||:.||||:.||||||||:|||
Zfish   318 VCGLKWSTDHQLLASGGNDNKLLVWNHSSVLPMQQYTEHLAAVKAIAWSPHQHGLLASGGGTADR 382

  Fly   339 CLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQR 403
            |:||||.||.:.::||:||:|:.||||::.:.|||:|||::|.|::.|:||||.|:|:|:||:.|
Zfish   383 CIRFWNTLTAQPLQCIDTGSQVCNLAWSKHTNELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYR 447

  Fly   404 VLHLSVSPDNESIVTGGADETLRFWTVFTKQKISKEPNSVLRLFKGIR 451
            ||:|::|||.|:||||..|||||||.||:|.:.:||..|||.||..||
Zfish   448 VLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40 repeat	149..185	CDD:293791	25/35 (71%)
		WD40	<159..436	CDD:441893	160/276 (58%)
		WD40 repeat	190..227	CDD:293791	16/36 (44%)
		WD40 repeat	233..269	CDD:293791	22/35 (63%)
		WD40 repeat	274..310	CDD:293791	18/35 (51%)
		WD40 repeat	317..355	CDD:293791	25/37 (68%)
		WD40 repeat	360..398	CDD:293791	19/37 (51%)
		WD40 repeat	404..436	CDD:293791	21/31 (68%)
fzr1a	NP_956547.1	WD40	<202..474	CDD:441893	157/271 (58%)
		WD40 repeat	234..271	CDD:293791	16/36 (44%)
		WD40 repeat	277..313	CDD:293791	22/35 (63%)
		WD40 repeat	318..354	CDD:293791	18/35 (51%)
		WD40 repeat	361..399	CDD:293791	25/37 (68%)
		WD40 repeat	404..442	CDD:293791	19/37 (51%)
		WD40 repeat	448..489	CDD:293791	25/40 (63%)