Protein Alignment fzr2 and Fzr1

DIOPT Version :10

• Sequence 1: NP_611854.1
• Gene: fzr2 / 37808
• FlyBaseID: FBgn0034937
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001101544.2
• Gene: Fzr1 / 314642
• RGDID: 1308713
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 498
• Identity: 232/498 - (46%)
• Similarity: 321/498 - (64%)
• Gaps: 59/498 - (11%)

  Fly     5 EYQQRLLPGVAVGKKEDIDL-----------------------RCIPTRAGNHWNRNF--VN--- 41
            :|::|||..:.:..:..:..                       |.||:|||.:|:.||  :|
  Rat     4 DYERRLLRQIIIQNENTVPCVSEMRRTLTPANSPVSSPSKHGDRFIPSRAGANWSVNFHRINENE 68

  Fly    42 -APGDS---------NVYESSVYSCLLRNEFLDENITSLENCEQTAQVHAQTDDFR-----DRHN 91
             :|..:         |..:...||.||:||.|...|..:::        .||:|.|     ..|.
  Rat    69 KSPSQNRKAKDATSDNGKDGLAYSALLKNELLGAGIEKVQD--------PQTEDRRLQPSTPEHK 125

  Fly    92 RIFGFASGS--SSPVR----TPF--ANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYL 148
            .:|.::..|  |||..    :|:  :.:|..||:||...::|.|::.:.|:|:||||||||||||
  Rat   126 GLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLDAPELQDDFYL 190

  Fly   149 NLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTI 213
            ||:||||.|.|:||||..||||||.:.|||||||.:.|.:.:|:|.|...|..||:||..|:|.|
  Rat   191 NLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQI 255

  Fly   214 WDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQ 278
            |||...|:::.||.|:|||.||||..::|:||||||.|||||||.|.....|.|:||:.|||||:
  Rat   256 WDAAAGKKLSVLEGHTARVGALAWNADQLSSGSRDRMILQRDIRTPALQSERRLQGHRQEVCGLK 320

  Fly   279 WSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFW 343
            ||..::.|||||:||:||||......|:..:.||.|.|||:.||||:.||||||||:||||:|||
  Rat   321 WSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFW 385

  Fly   344 NVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLS 408
            |.|||:.::||:||:|:.||||::.:.|||:|||::|.|::.|:||||.|:|:|:||:.|||:|:
  Rat   386 NTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLA 450

  Fly   409 VSPDNESIVTGGADETLRFWTVFTKQKISKEPNSVLRLFKGIR 451
            :|||.|:||||..|||||||.||:|.:.:||..|||.||..||
  Rat   451 MSPDGEAIVTGAGDETLRFWNVFSKTRSTKESVSVLNLFTRIR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40 repeat	149..185	CDD:293791	25/35 (71%)
		WD40	<159..436	CDD:441893	160/276 (58%)
		WD40 repeat	190..227	CDD:293791	16/36 (44%)
		WD40 repeat	233..269	CDD:293791	21/35 (60%)
		WD40 repeat	274..310	CDD:293791	18/35 (51%)
		WD40 repeat	317..355	CDD:293791	26/37 (70%)
		WD40 repeat	360..398	CDD:293791	19/37 (51%)
		WD40 repeat	404..436	CDD:293791	21/31 (68%)
Fzr1	NP_001101544.2	WD40	<200..472	CDD:441893	157/271 (58%)
		WD40 repeat	232..269	CDD:293791	16/36 (44%)
		WD40 repeat	275..311	CDD:293791	21/35 (60%)
		WD40 repeat	316..352	CDD:293791	18/35 (51%)
		WD40 repeat	359..397	CDD:293791	26/37 (70%)
		WD40 repeat	402..440	CDD:293791	19/37 (51%)
		WD40 repeat	446..487	CDD:293791	25/40 (63%)