DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and slp1

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_593161.1	Gene:	slp1 / 2543222	PomBaseID:	SPAC821.08c	Length:	488	Species:	Schizosaccharomyces pombe

Alignment Length:	489	Identity:	152/489 - (31%)
Similarity:	235/489 - (48%)	Gaps:	83/489 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YQQRLLPGVAVGKKEDIDLRCIP-----------------------------TRAGNHWNRNFVN 41
            :||.||     |:......||.|                             :|..:..:|...:
pombe    34 HQQALL-----GRNGRSSKRCSPKSSFIRNSPKIDVVNTDWSIPLCGSPRNKSRPASRSDRFIPS 93

  Fly    42 APGDSNVYESSVYSCLLRNEFLDENITSLENC--EQTAQVHA---------QTDDFRDRHNRIFG 95
            .|..:|.:.:|:.|    :...|.:.:..|.|  :...:|.|         :..|.|.:|||
pombe    94 RPNTANAFVNSISS----DVPFDYSESVAEACGFDLNTRVLAFKLDAPEAKKPVDLRTQHNR--- 151

  Fly    96 FASGSSSPVRTPFANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYLNLIDWSSKNTLA 160
                ...||.||                 ..||....|.::||||.:.||:||||:|||:.|.:|
pombe   152 ----PQRPVVTP-----------------AKRRFNTTPERVLDAPGIIDDYYLNLLDWSNLNVVA 195

  Fly   161 VGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQKQINRL 225
            |.|..:||:|:|.||.|:.|.: .:|...:.:|.|..:|..:::|..:|.|.|:|.|:|.::..:
pombe   196 VALERNVYVWNADSGSVSALAE-TDESTYVASVKWSHDGSFLSVGLGNGLVDIYDVESQTKLRTM 259

  Fly   226 EEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQWSPSNRYLASGG 290
            ..|.|||..|:|..:.|:||||..:|...|:| ...|....|:||..|||||.|......|||||
pombe   260 AGHQARVGCLSWNRHVLSSGSRSGAIHHHDVR-IANHQIGTLQGHSSEVCGLAWRSDGLQLASGG 323

  Fly   291 SDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFWNVLTGKLVKCIN 355
            :||.:.:|......|.:....|.|.|||:.|.|.:|.|||:|||:.|:.:.|||..||..|..::
pombe   324 NDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAATGARVNTVD 388

  Fly   356 TGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPS--LKQMARLSGHTQRVLHLSVSPDNESIVT 418
            .|:|:::|.|:..|:|:::|||.....:..|.|.|  |.:...:..|..|||:.::|||...:.|
pombe   389 AGSQVTSLIWSPHSKEIMSTHGFPDNNLSIWSYSSSGLTKQVDIPAHDTRVLYSALSPDGRILST 453

  Fly   419 GGADETLRFWTVFTKQ------KISKEPNSVLRL 446
            ..:||.|:||.|:...      .|:|.|:|.:.:
pombe   454 AASDENLKFWRVYDGDHVKRPIPITKTPSSSITI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	125/345 (36%)
		WD40 repeat	149..185	CDD:293791	17/35 (49%)
		WD40	190..446	CDD:295369	95/263 (36%)
		WD40 repeat	190..227	CDD:293791	10/36 (28%)
		WD40 repeat	233..269	CDD:293791	12/35 (34%)
		WD40 repeat	274..310	CDD:293791	14/35 (40%)
		WD40 repeat	317..355	CDD:293791	18/37 (49%)
		WD40 repeat	360..398	CDD:293791	11/39 (28%)
		WD40 repeat	404..436	CDD:293791	12/37 (32%)
slp1	NP_593161.1	WD40	<164..487	CDD:225201	122/324 (38%)
		WD40	202..464	CDD:295369	98/263 (37%)
		WD40 repeat	225..261	CDD:293791	10/35 (29%)
		WD40 repeat	266..301	CDD:293791	12/35 (34%)
		WD40 repeat	309..343	CDD:293791	12/33 (36%)
		WD40 repeat	349..388	CDD:293791	19/38 (50%)
		WD40 repeat	393..433	CDD:293791	11/39 (28%)
		WD40 repeat	439..463	CDD:293791	9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54440
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820