DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and srw1

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_594674.1	Gene:	srw1 / 2542824	PomBaseID:	SPAC144.13c	Length:	556	Species:	Schizosaccharomyces pombe

Alignment Length:	479	Identity:	181/479 - (37%)
Similarity:	254/479 - (53%)	Gaps:	78/479 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RCIPTRAGNH--WNRNFVNAPG------------DSNVYESSVYSCLLRNEFLDENITSLENCE- 74
            |.||:|..:.  |. .|....|            |.|      ::.|||:|....|..:..|..
pombe    75 RFIPSRDASTELWT-GFTKVEGPLTPVKKKQSVADRN------FTTLLRSELFGSNDETFNNSPI 132

  Fly    75 ---------QTAQVHAQTDDF-----------------------------------RDRHNRIFG 95
                     .|.:..:..||.                                   |||:...:|
pombe   133 ATPNTTIGVSTPRTDSGIDDIELTQRTPPSSSHTSSSILQNTPVTPSRKIFHYLSPRDRNKSSYG 197

  Fly    96 -FASGSSSPVRT-----PFANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYLNLIDWS 154
             .|....:|.||     |..:|::.   |:|..:...|.||..||::||||.|..||||||:||.
pombe   198 KKAQYQDNPNRTIYSLSPVRSITKD---LISASRLEGRELPSIPYRVLDAPGLAGDFYLNLLDWG 259

  Fly   155 SKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVTIWDAENQ 219
            ..|.|||.|...|||||.:|.:||.:.:|...|. :|::.|...|..:|:||.:|.|.||||...
pombe   260 QCNMLAVALASRVYLWSGISSEVTVMHNFYPTDT-VTSLRWVQRGTHLAVGTHNGSVEIWDAATC 323

  Fly   220 KQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHKLEVCGLQWSPSNR 284
            |:...:..|:.||.||:|..:.|:||.||..||.||:| .|.|..|.|..|:.|||||:|:.:..
pombe   324 KKTRTMSGHTERVGALSWNDHVLSSGGRDNHILHRDVR-APEHYFRVLTAHRQEVCGLEWNSNEN 387

  Fly   285 YLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSADRCLRFWNVLTGK 349
            .|||||:||.|:||.....:|:|:|..|.|.|||:.||||:.|:||||||:|||.::.||...|.
pombe   388 LLASGGNDNALMVWDKFEEKPLYSFHNHIAAVKAITWSPHQRGILASGGGTADRTIKLWNTQRGS 452

  Fly   350 LVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMARLSGHTQRVLHLSVSPDNE 414
            ::..|:||:|:.||.|::.:.|.::|||..:.:|..|.|||:.::..|.|||.|||:|::||:.|
pombe   453 MLHNIDTGSQVCNLLWSKQTNEFISTHGFMENEVALWNYPSVSRVGTLKGHTDRVLYLAMSPNGE 517

  Fly   415 SIVTGGADETLRFWTVF-TKQKIS 437
            :||||.||||||||.:| :|.|.|
pombe   518 NIVTGAADETLRFWKLFDSKSKHS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	158/343 (46%)
		WD40 repeat	149..185	CDD:293791	18/35 (51%)
		WD40	190..446	CDD:295369	118/249 (47%)
		WD40 repeat	190..227	CDD:293791	13/36 (36%)
		WD40 repeat	233..269	CDD:293791	17/35 (49%)
		WD40 repeat	274..310	CDD:293791	17/35 (49%)
		WD40 repeat	317..355	CDD:293791	19/37 (51%)
		WD40 repeat	360..398	CDD:293791	12/37 (32%)
		WD40 repeat	404..436	CDD:293791	20/32 (63%)
srw1	NP_594674.1	WD40	<272..536	CDD:225201	125/265 (47%)
		WD40	291..532	CDD:238121	114/242 (47%)
		WD40 repeat	295..331	CDD:293791	13/35 (37%)
		WD40 repeat	336..370	CDD:293791	17/34 (50%)
		WD40 repeat	378..413	CDD:293791	16/34 (47%)
		WD40 repeat	419..455	CDD:293791	20/35 (57%)
		WD40 repeat	463..501	CDD:293791	12/37 (32%)
		WD40 repeat	507..531	CDD:293791	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1832
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		mtm9276
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1507
TreeFam	1	0.960	-	-
	8	7.870