DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and mfr1

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_595081.1	Gene:	mfr1 / 2540043	PomBaseID:	SPBC1198.12	Length:	421	Species:	Schizosaccharomyces pombe

Alignment Length:	441	Identity:	200/441 - (45%)
Similarity:	270/441 - (61%)	Gaps:	43/441 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RCIPTR-AGNHWNRNF------VNAPGDSNVYESSVYSCLLRNEFLDENITSLE----------- 71
            |.||.| ..|.:|.:|      |.:.| ||:...:  |..::.:|::  :.|:|
pombe     4 RFIPIRNVSNEFNFSFQSFKECVLSHG-SNLRRKT--SGTIQRQFME--LLSMELFGSQASRSRA 63

  Fly    72 --NCEQTAQVHAQTDDFRDRHNRIFGFASGSSSPVRTPFANISESSQRLLSIFKRPMRRLPRRPY 134
              ..|...::..:..|..||       .|.|.||       ||..||.:|...::|.|..|:.||
pombe    64 FYYGEDKRKIEKKMLDTPDR-------KSYSLSP-------ISPQSQDMLRQPQKPKRAFPKTPY 114

  Fly   135 KILDAPELQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEG 199
            ||||||.|::||||||:||...|.|||||..|:|||||.||:|.:|.|| ...|.:|:|.|.|:|
pombe   115 KILDAPYLKNDFYLNLLDWGQSNVLAVGLASSIYLWSAASGKVVQLHDF-GATNHVTSVLWTGKG 178

  Fly   200 RQVAIGTQSGYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHIT 264
            .|:|:||.||.:.|||.|:.|.:..|:.||.||.||||..|.|.||.:|..||..|:|.|.. ..
pombe   179 TQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWNDNTLTSGGKDEVILHHDLRAPGC-CA 242

  Fly   265 RCLRGHKLEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLL 329
            ..::.|:.|:|||||..|...|||||:||.|.||......|::.|:||.|.|||:|||||:.|:|
pombe   243 EMMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQRGIL 307

  Fly   330 ASGGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQM 394
            |||||:.||||...|.|||:|...::||:|:.|:||::.|.|:|||||.|:.||..|:|||||.:
pombe   308 ASGGGTIDRCLTIHNTLTGRLQNKLDTGSQVCNMAWSKTSNEIVTTHGFAKNQVSLWKYPSLKNI 372

  Fly   395 ARLSGHTQRVLHLSVSPDNESIVTGGADETLRFWTVFTKQKISKEPNSVLR 445
            |.|:.||.|||:||:|||.:|||||..|||||||.:|.|:  .||.::::|
pombe   373 ANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKLFNKK--PKEESTLIR 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	176/337 (52%)
		WD40 repeat	149..185	CDD:293791	22/35 (63%)
		WD40	190..446	CDD:295369	133/256 (52%)
		WD40 repeat	190..227	CDD:293791	17/36 (47%)
		WD40 repeat	233..269	CDD:293791	14/35 (40%)
		WD40 repeat	274..310	CDD:293791	17/35 (49%)
		WD40 repeat	317..355	CDD:293791	23/37 (62%)
		WD40 repeat	360..398	CDD:293791	20/37 (54%)
		WD40 repeat	404..436	CDD:293791	21/31 (68%)
mfr1	NP_595081.1	WD40	<134..414	CDD:225201	149/283 (53%)
		WD40	135..407	CDD:295369	146/273 (53%)
		WD40 repeat	169..206	CDD:293791	17/36 (47%)
		WD40 repeat	212..247	CDD:293791	14/35 (40%)
		WD40 repeat	252..288	CDD:293791	17/35 (49%)
		WD40 repeat	295..333	CDD:293791	23/37 (62%)
		WD40 repeat	338..376	CDD:293791	20/37 (54%)
		WD40 repeat	382..408	CDD:293791	19/25 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I1832
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	394	1.000	Inparanoid score	I397
OMA	1	1.010	-	-		QHG54440
OrthoFinder	1	1.000	-	-		FOG0000628
OrthoInspector	1	1.000	-	-		mtm9276
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1507
TreeFam	1	0.960	-	-
	10	9.930