DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and mug55

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_588462.1	Gene:	mug55 / 2539258	PomBaseID:	SPCC1620.04c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	440	Identity:	118/440 - (26%)
Similarity:	207/440 - (47%)	Gaps:	59/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RCIPTRAGNHWNRNFVNAPGDS-NVYESSVYSCLLRNEFLDENITSL----ENCEQ-TAQVHAQT 83
            |.||::|.:...|...||..:. |..||      |..:.|:.|:..:    :|.:| |.::...|
pombe    56 RFIPSKANSDAFRIMENAFTEKLNTQES------LLPDILNLNVKGVLHYKDNKKQKTTRLIEST 114

  Fly    84 DDFRDRHNRIFGFASGSSSPVRTPFANISESSQRLLSIFKRPMRRLPRRPYKILDAPELQDDFYL 148
            :..|..       ..|:||.:..........|....|:::.|:|        |||||.|.||||:
pombe   115 NYQRQT-------IHGASSSLVIEVEENGHLSNMQGSLYETPLR--------ILDAPGLLDDFYI 164

  Fly   149 NLIDWSSKNTLAVGLGCSVYLWSAVSG-QVTRLCDFNNEDNLITAVSWHGEGRQVAIGTQSGYVT 212
            :.:.||:...|||.|..:|||||.:|| .:..|.....|   ::::::..:|..:||...:|:|.
pombe   165 SPLAWSTNGELAVALAQNVYLWSEISGPSIMELSPTTYE---VSSLAYSSDGGFLAIARVNGFVE 226

  Fly   213 IWDAENQKQINRLE---EHSARVTALAWC---GNRLASGSRDRSILQRDIRNPPTHITRCLRGHK 271
            ||:.:.:.  ||.:   .|...::.:||.   ...|..||.....:.|..::....:....:.|:
pombe   227 IWNRKTKN--NRCDYKFHHDGDISCMAWSPINWTLLVGGSTGNIYVYRRTKSMMRRVHTIKKVHQ 289

  Fly   272 LEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPEPIYAFDEHKAVVKALGWSPHKSGLLASGGGSA 336
            .:||||:|:......||||:||.:.::..|..|....:..|.|.||||.:.|.:..|||.|.||.
pombe   290 EQVCGLEWNYDGTQFASGGNDNLVCIFDIDSLENKKFYWIHLAAVKALAFCPWQKSLLAVGTGSN 354

  Fly   337 DRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHA----QPQVIAWRYPSLKQM--- 394
            |:.:.|::...|..:..:..|||::::.|:|..:|...:.|::    ...:|.:|:|.|.::
pombe   355 DQQIYFYDTFRGHRIHSLFCGAQVTSVIWSRRYKEFCYSLGYSPEGTNSSLIVYRWPQLTKVFDI 419

  Fly   395 --ARLSG-----------HTQRVLHLSVSPDNESIVTGGADETLRFWTVF 431
              |.:.|           ||.|....:...:.|.:|...:|||::|:.::
pombe   420 PSAAIDGWGQDLRTIMAIHTHRKYSNNTWEEGEYVVVANSDETVKFYKIW 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	99/358 (28%)
		WD40 repeat	149..185	CDD:293791	14/36 (39%)
		WD40	190..446	CDD:295369	68/268 (25%)
		WD40 repeat	190..227	CDD:293791	9/39 (23%)
		WD40 repeat	233..269	CDD:293791	6/38 (16%)
		WD40 repeat	274..310	CDD:293791	13/35 (37%)
		WD40 repeat	317..355	CDD:293791	13/37 (35%)
		WD40 repeat	360..398	CDD:293791	9/46 (20%)
		WD40 repeat	404..436	CDD:293791	6/28 (21%)
mug55	NP_588462.1	WD40	<163..468	CDD:225201	84/309 (27%)
		WD40	164..384	CDD:295369	64/224 (29%)
		WD40 repeat	164..200	CDD:293791	14/35 (40%)
		WD40 repeat	205..242	CDD:293791	9/38 (24%)
		WD40 repeat	247..285	CDD:293791	6/37 (16%)
		WD40 repeat	293..327	CDD:293791	12/33 (36%)
		WD40 repeat	334..365	CDD:293791	13/30 (43%)
		WD40 repeat	443..478	CDD:293791	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810