DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fzr2 and cdc20b

DIOPT Version :9

Sequence 1:	NP_611854.1	Gene:	fzr2 / 37808	FlyBaseID:	FBgn0034937	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	XP_004910413.1	Gene:	cdc20b / 100497347	XenbaseID:	XB-GENE-1013871	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	292	Identity:	115/292 - (39%)
Similarity:	164/292 - (56%)	Gaps:	8/292 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 LQDDFYLNLIDWSSKNTLAVGLGCSVYLWSAVSGQVTRLCDFNNEDNLITAVSWHGEGRQVAIGT 206
            |.:|:||||:||:|:|.:|:||..:.|::|..:..||:....:.....:::|||...|..:||||
Frog   227 LHNDYYLNLLDWNSENLVAIGLKSTAYIFSGENRTVTQKIHLSCPATYVSSVSWISSGTCLAIGT 291

  Fly   207 QSGYVTIWDAENQKQINRLEEHSARVTALAWCGNRLASGSRDRSILQRDIRNPPTHITRCLRGHK 271
            .||.|.:||.|.||::..:..|.:.|.||:|..:.|:||||...|...|:|....||...  .||
Frog   292 SSGEVQLWDIETQKRLRNMLGHMSVVGALSWNNHILSSGSRLGHIHHHDVRIAEHHIGTL--QHK 354

  Fly   272 LEVCGLQWSPSNRYLASGGSDNRLLVWTDDWPE-----PIYAFDEHKAVVKALGWSPHKSGLLAS 331
            ..:|.|:|||....||||.||..|.:|..|..|     |:... .|...|||:.|.|..|..||.
Frog   355 QGICSLKWSPCGNKLASGSSDGDLKIWPCDPGETKLKSPLLNM-PHPTAVKAMNWCPWLSDTLAV 418

  Fly   332 GGGSADRCLRFWNVLTGKLVKCINTGAQISNLAWARDSRELVTTHGHAQPQVIAWRYPSLKQMAR 396
            |||..|..:|.|:..:||.:...||.:||.:|.|...::||:|.||.::.|:..|:||||.:|..
Frog   419 GGGMTDGLIRIWDTNSGKNIHSANTNSQICSLLWLPQTKELLTGHGPSRNQMTIWQYPSLLKMND 483

  Fly   397 LSGHTQRVLHLSVSPDNESIVTGGADETLRFW 428
            ..||..|||||::|||...|.:..|:.|...|
Frog   484 YYGHKGRVLHLALSPDQRRIFSAAANGTANIW 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fzr2	NP_611854.1	WD40	<101..439	CDD:225201	115/292 (39%)
		WD40 repeat	149..185	CDD:293791	13/35 (37%)
		WD40	190..446	CDD:295369	98/244 (40%)
		WD40 repeat	190..227	CDD:293791	16/36 (44%)
		WD40 repeat	233..269	CDD:293791	13/35 (37%)
		WD40 repeat	274..310	CDD:293791	16/40 (40%)
		WD40 repeat	317..355	CDD:293791	15/37 (41%)
		WD40 repeat	360..398	CDD:293791	15/37 (41%)
		WD40 repeat	404..436	CDD:293791	11/25 (44%)
cdc20b	XP_004910413.1	WD40	<220..516	CDD:225201	115/292 (39%)
		WD40 repeat	234..270	CDD:293791	13/35 (37%)
		WD40 repeat	275..312	CDD:293791	16/36 (44%)
		WD40 repeat	318..349	CDD:293791	12/30 (40%)
		WD40 repeat	357..396	CDD:293791	16/38 (42%)
		WD40 repeat	404..440	CDD:293791	15/35 (43%)
		WD40 repeat	447..485	CDD:293791	15/37 (41%)
		WD40 repeat	491..517	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1220675at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920