DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stoml2 and PHB

DIOPT Version :9

Sequence 1:	NP_001261161.1	Gene:	Stoml2 / 37807	FlyBaseID:	FBgn0034936	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001268425.1	Gene:	PHB / 5245	HGNCID:	8912	Length:	272	Species:	Homo sapiens

Alignment Length:	244	Identity:	58/244 - (23%)
Similarity:	98/244 - (40%)	Gaps:	66/244 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RFHRILD----PGLNILVPVADKIKYVQSLKEIAID-------VPKQSAITSD------NVTLSI 106
            ||..:.|    .|.:.|:|      :||  |.|..|       ||   .||..      |:||.|
Human    41 RFRGVQDIVVGEGTHFLIP------WVQ--KPIIFDCRSRPRNVP---VITGSKDLQNVNITLRI 94

  Fly   107 DGVLYLRIIDPYK---ASYGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNVSIVDSINK 168
               |:..:.....   .|.|.:..|..:..:....::|.:.:....::..:||.::..:.|.:.:
Human    95 ---LFRPVASQLPRIFTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTE 156

  Fly   169 ASEAWGIACLRYEIRDIRLP--------TRVHEAMQM-QVEAER----------RKRAAILESEG 214
            .:..:|:.     :.|:.|.        |...||.|: |.||||          :|:|||:.:||
Human   157 RAATFGLI-----LDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEG 216

  Fly   215 VREAEINIAEGKRKSRILASEAERQEHINKASGEAAAIIAVADARARSL 263
            ..:|...||..      ||:..:....:.|.  |||..||...:|:|::
Human   217 DSKAAELIANS------LATAGDGLIELRKL--EAAEDIAYQLSRSRNI 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stoml2	NP_001261161.1	PHB	41..199	CDD:214581	34/168 (20%)
		SPFH_paraslipin	80..188	CDD:259811	23/123 (19%)
		Band_7_C	266..326	CDD:292817
PHB	NP_001268425.1	SPFH_prohibitin	27..221	CDD:259799	45/198 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810