DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stoml2 and STOM

DIOPT Version :9

Sequence 1:	NP_001261161.1	Gene:	Stoml2 / 37807	FlyBaseID:	FBgn0034936	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_004090.4	Gene:	STOM / 2040	HGNCID:	3383	Length:	288	Species:	Homo sapiens

Alignment Length:	206	Identity:	65/206 - (31%)
Similarity:	121/206 - (58%)	Gaps:	15/206 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PIN--MCVMFVPQQEAWVVERMGRFHRILD-----PGLNILVPVADKIKYVQSLKEIAIDVPKQS 95
            ||:  ||:..:.:.|..::.|:|   |||.     |||..::|..|....| .::.|:.|:|.|.
Human    47 PISIWMCIKIIKEYERAIIFRLG---RILQGGAKGPGLFFILPCTDSFIKV-DMRTISFDIPPQE 107

  Fly    96 AITSDNVTLSIDGVLYLRIIDPYKASYGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNV 160
            .:|.|:||:|:|||:|.|:.:...|...:.:.:.|...|||||:|:.||..::.::..:||.:..
Human   108 ILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAH 172

  Fly   161 SIVDSINKASEAWGIACLRYEIRDIRLPTRVHEAMQMQVEAERRKRAAILESEGVREAEINIAEG 225
            ::..:::.|::||||...|.||:|::||.::..||..:.||.|..||.::.:||    |:|.:..
Human   173 NMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEG----EMNASRA 233

  Fly   226 KRKSRILASEA 236
            .:::.::.:|:
Human   234 LKEASMVITES 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stoml2	NP_001261161.1	PHB	41..199	CDD:214581	53/162 (33%)
		SPFH_paraslipin	80..188	CDD:259811	36/107 (34%)
		Band_7_C	266..326	CDD:292817
STOM	NP_004090.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SPFH_stomatin	73..274	CDD:259801	55/177 (31%)
		Required for homooligomerization	265..273
		Required for lipid raft association	267..269
		Interaction with LANCL1. /evidence=ECO:0000269\|PubMed:9512664	273..287
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810