DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Stoml2 and Nphs2

DIOPT Version :9

Sequence 1:	NP_001261161.1	Gene:	Stoml2 / 37807	FlyBaseID:	FBgn0034936	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_569723.1	Gene:	Nphs2 / 170484	MGIID:	2157018	Length:	385	Species:	Mus musculus

Alignment Length:	288	Identity:	69/288 - (23%)
Similarity:	125/288 - (43%)	Gaps:	46/288 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 CVMFVPQQEAWVVERMGRF--HRILDPGLNILVPVADKIKYVQSLKEIAIDVPKQSAITSDNVTL 104
            |:..|.:.|..::.|:|..  .|...|||...:|..|....| .|:...:::|....:|.|...:
Mouse   126 CIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKV-DLRLQTLEIPFHEVVTKDMFIM 189

  Fly   105 SIDGVLYLRIIDPYKASYGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNVSIVDSINKA 169
            .||.|.|.|:.:.......:.....||..|.||||:..|...|:.::..||:|:...:..:::..
Mouse   190 EIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDAV 254

  Fly   170 SEAWGIACLRYEIRDIRLPTRVHEAMQMQVEAERRKRAAILESEGVREAEINIAEGKRKSRILAS 234
            :..|||...|.||:|:|||..:..::.::.||:|:.:..::.:||.:.|.        :|..:|:
Mouse   255 TCIWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAAEGEKAAS--------ESLRMAA 311

  Fly   235 EAERQEHINKASGEAAAIIAVADARARSLLAIAKSLSHLDGQNAASLTLAEQYIGAFKKLAKTNN 299
            |.        .||..||:          .|....:|..|..:..|::.|...:           :
Mouse   312 EI--------LSGTPAAV----------QLRYLHTLQSLSTEKPATVVLPLPF-----------D 347

  Fly   300 TMILPSNPGDVNGFVAQALAVYNHVSNS 327
            .:.|.|:||:      :|....|:.|:|
Mouse   348 MLSLLSSPGN------RAQGSINYPSSS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stoml2	NP_001261161.1	PHB	41..199	CDD:214581	43/158 (27%)
		SPFH_paraslipin	80..188	CDD:259811	30/107 (28%)
		Band_7_C	266..326	CDD:292817	10/59 (17%)
Nphs2	NP_569723.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64
		SPFH_podocin	124..346	CDD:259809	61/246 (25%)
		PHB	125..289	CDD:214581	45/163 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..385		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810