DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stoml2 and Phb2

DIOPT Version :9

Sequence 1:	NP_001261161.1	Gene:	Stoml2 / 37807	FlyBaseID:	FBgn0034936	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001013053.1	Gene:	Phb2 / 114766	RGDID:	620203	Length:	299	Species:	Rattus norvegicus

Alignment Length:	246	Identity:	46/246 - (18%)
Similarity:	99/246 - (40%)	Gaps:	60/246 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDPGLNILVPVADKIKYVQSLKEIAIDV---PKQSAITSDNVTLSIDGVLYLRIIDPYKAS--- 121
            ||..||:..:|   ..:|     .|..|:   |::.:..:.:..|.:..: .||::....|.
  Rat    63 ILAEGLHFRIP---WFQY-----PIIYDIRARPRKISSPTGSKDLQMVNI-SLRVLSRPNAQELP 118

  Fly   122 -----YGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNVSIVDSINKASEAWGIACLRYE 181
                 .|::..|..:..:....::|.:.|.:..::..:|..:::.|...:.:.::.:.:......
  Rat   119 SMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVA 183

  Fly   182 IRDI---RLPTRVHEAMQM-QVEAERRKRAAILESEGVREAEINIAEGKRKSRILASEAERQEHI 242
            |.::   |..|...||.|: |.||:|              |:..:.:.|:         |:::.|
  Rat   184 ITELSFSREYTAAVEAKQVAQQEAQR--------------AQFLVEKAKQ---------EQRQKI 225

  Fly   243 NKASGEAAAIIAVADA-----------RARSLLAIAKSLSHLDGQNAASLT 282
            .:|.|||.|...:.:|           :.|:...|:|:::  ..||...||
  Rat   226 VQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIA--TSQNRIYLT 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stoml2	NP_001261161.1	PHB	41..199	CDD:214581	25/150 (17%)
		SPFH_paraslipin	80..188	CDD:259811	16/121 (13%)
		Band_7_C	266..326	CDD:292817	6/17 (35%)
Phb2	NP_001013053.1	Necessary for transcriptional repression. /evidence=ECO:0000250\|UniProtKB:Q99623	19..49
		PHB	39..201	CDD:214581	24/146 (16%)
		SPFH_prohibitin	40..235	CDD:259799	37/203 (18%)
		Necessary for transcriptional repression. /evidence=ECO:0000250\|UniProtKB:Q99623	150..174		2/23 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900