DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Stoml2 and PHB2

DIOPT Version :9

Sequence 1:	NP_001261161.1	Gene:	Stoml2 / 37807	FlyBaseID:	FBgn0034936	Length:	366	Species:	Drosophila melanogaster
Sequence 2:	NP_001138303.1	Gene:	PHB2 / 11331	HGNCID:	30306	Length:	299	Species:	Homo sapiens

Alignment Length:	246	Identity:	46/246 - (18%)
Similarity:	99/246 - (40%)	Gaps:	60/246 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ILDPGLNILVPVADKIKYVQSLKEIAIDV---PKQSAITSDNVTLSIDGVLYLRIIDPYKAS--- 121
            ||..||:..:|   ..:|     .|..|:   |::.:..:.:..|.:..: .||::....|.
Human    63 ILAEGLHFRIP---WFQY-----PIIYDIRARPRKISSPTGSKDLQMVNI-SLRVLSRPNAQELP 118

  Fly   122 -----YGVEDPEFAITQLAQTTMRSELGKMSMDKVFRERESLNVSIVDSINKASEAWGIACLRYE 181
                 .|::..|..:..:....::|.:.|.:..::..:|..:::.|...:.:.::.:.:......
Human   119 SMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVA 183

  Fly   182 IRDI---RLPTRVHEAMQM-QVEAERRKRAAILESEGVREAEINIAEGKRKSRILASEAERQEHI 242
            |.::   |..|...||.|: |.||:|              |:..:.:.|:         |:::.|
Human   184 ITELSFSREYTAAVEAKQVAQQEAQR--------------AQFLVEKAKQ---------EQRQKI 225

  Fly   243 NKASGEAAAIIAVADA-----------RARSLLAIAKSLSHLDGQNAASLT 282
            .:|.|||.|...:.:|           :.|:...|:|:::  ..||...||
Human   226 VQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIA--TSQNRIYLT 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Stoml2	NP_001261161.1	PHB	41..199	CDD:214581	25/150 (17%)
		SPFH_paraslipin	80..188	CDD:259811	16/121 (13%)
		Band_7_C	266..326	CDD:292817	6/17 (35%)
PHB2	NP_001138303.1	Necessary for transcriptional repression. /evidence=ECO:0000269\|PubMed:10359819	19..49
		SPFH_prohibitin	40..235	CDD:259799	37/203 (18%)
		LC3-interaction region. /evidence=ECO:0000269\|PubMed:28017329	121..124		0/2 (0%)
		Necessary for transcriptional repression. /evidence=ECO:0000269\|PubMed:10359819	150..174		2/23 (9%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810