DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and GNA14

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_004288.1	Gene:	GNA14 / 9630	HGNCID:	4382	Length:	355	Species:	Homo sapiens

Alignment Length:	371	Identity:	153/371 - (41%)
Similarity:	213/371 - (57%)	Gaps:	24/371 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80
            |.:.|..:|.|..|.|||::||:..|...:|||||.|||||||.:|||||:|..|:||.::|...
Human     8 SAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFT 72

  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDK 145
            ..:.:||..|:..:..||.||......|  :|:...:.|::...........|..|..::||:|.
Human    73 KLVYQNIFTAMQAMIRAMDTLRIQYVCE--QNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDP 135

  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210
            |:.:.|:|..||||.|.|||:|..:..|..|::.|.:||:||.||.|:||.|..|.::.:.|.|.
Human   136 GIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMV 200

  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275
            ||||||.||||||.||..||:|||:.|.|.|:.||.|...:||:.||..|||:|....|....|:
Human   201 DVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSV 265

  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRI- 339
            ||||||:|||.|||.  .|.|..||.|:        ||        ..:.:||   .||..|::
Human   266 ILFLNKKDLLEEKIM--YSHLISYFPEY--------TG--------PKQDVRA---ARDFILKLY 309

  Fly   340 STASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            ...:.|.:...|.|||||.||:||:.||...:|.|.:::||::.|:
Human   310 QDQNPDKEKVIYSHFTCATDTDNIRFVFAAVKDTILQLNLREFNLV 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	139/335 (41%)
GNA14	NP_004288.1	G_alpha	16..353	CDD:214595	150/359 (42%)
		G-alpha	36..349	CDD:206639	139/335 (41%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	37..50		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820