Protein Alignment Galphas and Gna12

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_112296.1
• Gene: Gna12 / 81663
• RGDID: 71018
• Length: 379
• Species: Rattus norvegicus
• Alignment Length: 369
• Identity: 135/369 - (36%)
• Similarity: 199/369 - (53%)
• Gaps: 26/369 - (7%)

  Fly    20 KSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIK 84
            :..:|||..|...|.::::..|...::||||||||||||.:|||||:|...|......:..|.|.
  Rat    32 REARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIF 96

  Fly    85 KNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYE----HTEELWKDK 145
            .||......:..|...|..|  .:..|||....::..:.:.......|..::    ....||:|.
  Rat    97 DNILKGSRVLVDARDKLGIP--WQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDS 159

  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210
            |:.:.:.|.:|:||.:..|||||.:..|...||.|::||||..|..|.||.|..|.:.|:.|.|.
  Rat   160 GIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 224

  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275
            ||||||.:|:||.|||:.:|:|:|:.:.|.|:.||.||...|||.||:::|::|.||:....:||
  Rat   225 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSI 289

  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRIS 340
            ||||||.|||.||:|:  ..:.::|.:|.        ||.  ...:|.:....:.|.|....|
  Rat   290 ILFLNKMDLLVEKVKS--VSIKKHFPDFK--------GDP--HRLEDVQRYLVQCFDRKRRNR-- 340

  Fly   341 TASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384
                 ||. .:.|||.|:|||||:.||:..:|.|.:.:|:...|
  Rat   341 -----GKP-LFHHFTTAIDTENIRFVFHAVKDTILQENLKDIML 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	127/338 (38%)
Gna12	NP_112296.1	G_alpha	40..377	CDD:214595	131/358 (37%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		10/12 (83%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		4/7 (57%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)