DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and Gna11

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_112295.1	Gene:	Gna11 / 81662	RGDID:	619749	Length:	359	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	147/372 - (39%)
Similarity:	213/372 - (57%)	Gaps:	26/372 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80
            |::.|..||.:..|.:||::||:..|...:|||||.|||||||.:|||||:|..|:|:.:|:...
  Rat    12 SDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGAGYSEEDKRGFT 76

  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYEHTEELWKDK 145
            ..:.:||..|:..:..||.||.  :..:.::|:.....|::........:..::....:.||.|.
  Rat    77 KLVYQNIFTAMQAVVRAMDTLK--IRYKYEQNKANALLIREVDVEKVTTFEHQYVNAIKTLWSDP 139

  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210
            ||.:.|:|..|:||.|.|||:|..|..|....|.|.:||:||.||.|:||.|..|.::.:.|.|.
  Rat   140 GVQECYDRRREFQLSDSAKYYLTDVDRIATVGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMV 204

  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275
            ||||||.||||||.||.:||:|:|:.|.|.|:.||.|...:||:.||..||::|....|.:..|:
  Rat   205 DVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQHSSV 269

  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDP--EVIRAKYFIRDEFLR 338
            ||||||:|||.:||.  .|.|.:||.||                 |.|  :...|:.||...|:.
  Rat   270 ILFLNKKDLLEDKIL--HSHLVDYFPEF-----------------DGPQRDAQAAREFILKMFVD 315

  Fly   339 ISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            ::.   |.....|.|||||.|||||:.||...:|.|.:::|::|.|:
  Rat   316 LNP---DSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	134/336 (40%)
Gna11	NP_112295.1	G_alpha	19..357	CDD:214595	143/361 (40%)
		G-alpha	40..353	CDD:206639	134/336 (40%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	41..54		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	178..186		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	201..210		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	329..334		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820