DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and gnav1

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001159486.1	Gene:	gnav1 / 571305	ZFINID:	ZDB-GENE-081031-92	Length:	362	Species:	Danio rerio

Alignment Length:	394	Identity:	148/394 - (37%)
Similarity:	203/394 - (51%)	Gaps:	41/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MG-CFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMR 64
            || |.|      |:|.:|:.|..|..|..|.|.|.:..:......::|||||.||||||:||||:
Zfish     1 MGLCLG------SEVTTEEDKKAKIHSSQIDRDLYEYAKRELNVVKILLLGAAESGKSTLVKQMK 59

  Fly    65 ILHVDGFSDSEKKQKIDDIKKNIRDAILT----ITGAMSTLNPPVALEKKENEPRVEYIQDYASS 125
            |:|..||:    ||::...|..:.|.:||    :...|..|.  :.|...:|:.....:......
Zfish    60 IIHSHGFT----KQELTSFKPAVLDNLLTSMKFVLHGMGVLR--INLANPKNKVHAHSVLSCGRC 118

  Fly   126 PDFN---YPPEFYEHTE-ELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDIL 186
            .|.:   :|  |..|.. .||.|.||..:..|..||:|.|.|.||.:.:..|...:|.|.|.|:|
Zfish   119 FDEDQMLFP--FIAHALCCLWADPGVRSSAARGYEYELNDSALYFFENMGRIIADDYMPTETDVL 181

  Fly   187 RCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQ 251
            |.|:.|:|:.||:|:|..:.|.|:||||||.||||||.||..|.:::||.:.|.|:|.|.|||:.
Zfish   182 RVRLRTTGVIETQFKVKHLVFRMYDVGGQRTERRKWISCFEYVRSVLFVVSLSGYDMTLVEDPSM 246

  Fly   252 NRLRESLDLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAI 316
            |||:|||.||.||.||.:.|..|:|||:||.||..|||......|..|..:|.
Zfish   247 NRLQESLKLFSSICNNIFFRGTSMILFMNKIDLFQEKILHSGRHLRHYLPQFR------------ 299

  Fly   317 MESNDDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQ 381
               ..|.:|..|..||.|.|:.::.:.   ....|.|||.|.||.|::.||....|.|.:.:|..
Zfish   300 ---GADCDVDAAARFIADMFVSLNASP---SKLIYHHFTTATDTSNVQVVFQVVMDTIIKENLEA 358

  Fly   382 YELL 385
            ..||
Zfish   359 VSLL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	132/342 (39%)
gnav1	NP_001159486.1	G_alpha	20..357	CDD:214595	136/362 (38%)
gnav1	NP_001159486.1	G-alpha	39..356	CDD:206639	132/342 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586301
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750