DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and gnal

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001007340.1	Gene:	gnal / 492467	ZFINID:	ZDB-GENE-041114-26	Length:	379	Species:	Danio rerio

Alignment Length:	385	Identity:	267/385 - (69%)
Similarity:	318/385 - (82%)	Gaps:	6/385 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||.|:..::...:   |.|:|:..:..|.:||||::|.|:||||||||||||||||||||||||
Zfish     1 MGCLGNSKTEDQRI---DEKAQREANKKIEKQLQKERQAYKATHRLLLLGAGESGKSTIVKQMRI 62

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130
            |||:||:..||||||.||:||::|||:||..|||||.|||::....|:||.|||:..|...||:|
Zfish    63 LHVNGFNAEEKKQKILDIRKNVKDAIVTIISAMSTLTPPVSIANPSNQPRAEYIKSIAPLSDFDY 127

  Fly   131 PPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGI 195
            ..||:||.:.||.|:||...:||||||||||||:|||:|:.:::..:|||.:||:||||||||||
Zfish   128 TEEFFEHAKHLWDDEGVKACFERSNEYQLIDCAQYFLERIESVRQNDYTPTDQDLLRCRVLTSGI 192

  Fly   196 FETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDL 260
            ||||||||||||||||||||||||||||||||||||||||.|.||||||:|||.:.|||||||||
Zfish   193 FETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVAASSSYNMVIREDNSTNRLRESLDL 257

  Fly   261 FKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEV 325
            |:|||.||:|||||:||||||||:|||||.||||||.:||.|:.:|..|   .:|..:..:||:|
Zfish   258 FRSIWTNRFLRTISVILFLNKQDMLAEKILAGKSKLEDYFPEYARYTLP---PEATPDPGEDPKV 319

  Fly   326 IRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            .|||:|||||||:||||||..|||||||||||||||||:.||||||||||||||||||||
Zfish   320 SRAKFFIRDEFLKISTASGTDKHYCYPHFTCAVDTENIRHVFNDCRDIIQRMHLRQYELL 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	243/334 (73%)
gnal	NP_001007340.1	G_alpha	20..376	CDD:214595	255/358 (71%)
gnal	NP_001007340.1	G-alpha	41..373	CDD:206639	243/334 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	537	1.000	Domainoid score	I264
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	572	1.000	Inparanoid score	I1021
OMA	1	1.010	-	-		QHG48884
OrthoDB	1	1.010	-	-		D325067at33208
OrthoFinder	1	1.000	-	-		FOG0004018
OrthoInspector	1	1.000	-	-		otm26292
orthoMCL	1	0.900	-	-		OOG6_106085
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3262
SonicParanoid	1	1.000	-	-		X2771
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870