DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and gna14

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001003753.1	Gene:	gna14 / 445297	ZFINID:	ZDB-GENE-040808-7	Length:	354	Species:	Danio rerio

Alignment Length:	375	Identity:	145/375 - (38%)
Similarity:	205/375 - (54%)	Gaps:	34/375 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80
            |.:.|.:.|....|.|:|:.|::......:|||||.|||||||.:|||||:|..|:::.:|:...
Zfish     7 SGEEKEKMRIHQEIERKLKMDRRSSNKELKLLLLGTGESGKSTFIKQMRIIHGKGYTEEDKRSFA 71

  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKE------NEPRVEYIQDYASSPDFNYPPEFYEHTE 139
            ..:.:|:..:|.::..||..|..|.|..|.|      .|...|.:|...:        ::.|..:
Zfish    72 KLVYQNVFTSIQSMLKAMENLKIPFAESKNETFAAMLKEVEAESVQTMEA--------KYAEAIK 128

  Fly   140 ELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDK 204
            .:|||:|:.:.|||..||||.|..||:||.:..|....|.|..|||||.||.|:||.|..|.:..
Zfish   129 SVWKDQGLQKCYERRREYQLSDSTKYYLDDMDRIAAGFYMPTLQDILRVRVPTTGIIEYVFDLQS 193

  Fly   205 VNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRW 269
            |.|.|.|||||:.||||||.||.:||::||:.|.|.|:..|.|...:||:.||..|||:|.:..|
Zfish   194 VLFRMVDVGGQKSERRKWIHCFENVTSVIFLVALSEYDQFLFESANENRMEESKALFKTIISYPW 258

  Fly   270 LRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRD 334
            .:..|:||||||.|:|.:||.  ||.|::|:.:|.   .|.:..||.|           |:.::
Zfish   259 FQDSSVILFLNKTDILKDKIL--KSDLAKYYPQFT---GPKNDADAAM-----------KFILK- 306

  Fly   335 EFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384
               .....:.|.:...|.|||||.|||||:.||...:|.|.|..|..:.|
Zfish   307 ---MYEEQNPDKQKRIYAHFTCATDTENIRFVFEAVKDTILRNTLSAFNL 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	136/340 (40%)
gna14	NP_001003753.1	G_alpha	15..348	CDD:214595	141/360 (39%)
gna14	NP_001003753.1	G-alpha	35..348	CDD:206639	136/340 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820