DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and gnao1b

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_957122.1	Gene:	gnao1b / 393801	ZFINID:	ZDB-GENE-040426-1693	Length:	354	Species:	Danio rerio

Alignment Length:	382	Identity:	162/382 - (42%)
Similarity:	206/382 - (53%)	Gaps:	35/382 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||          ..|.:.::...||.||.:.|::|........:|||||.||||||||||||:|
Zfish     1 MGC----------TLSAEERAALDRSRAIEKNLKEDGISAAKDVKLLLLGGGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFN- 129
            :|.||||..:.||....:..|...::..|..||.||.  :....|:.....:.:.|.....:..
Zfish    56 IHEDGFSGDDVKQFKPVVYSNTIQSLSAILRAMETLG--IEYSDKDRLADAKMVFDVVGRMEDTE 118

  Fly   130 -YPPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTS 193
             |..|.......||.|.|....:.||.||||.|.|:|:||.:..|.:|:|.|.||||||.||.|:
Zfish   119 PYSTELLAAMIRLWTDTGTQACFNRSREYQLNDSAQYYLDSLQRIGSPDYLPTEQDILRTRVKTT 183

  Fly   194 GIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESL 258
            ||.||.|....:||.:|||||||.||:|||.||.|||||||..|.|.|:.:|.||.|.||:.|||
Zfish   184 GIVETHFSFKNLNFRLFDVGGQRSERKKWIHCFEDVTAIIFCVAMSGYDQMLHEDETTNRMHESL 248

  Fly   259 DLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDP 323
            .||.||.||::....||||||||:||..|||.  ||.||..|.|:        ||....|:
Zfish   249 MLFDSICNNKFFVDTSIILFLNKKDLFGEKIV--KSPLSICFPEY--------TGPNTFEA---- 299

  Fly   324 EVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380
                |..:|:.:| .....|.:.:.||  |.|||.||.||:.||:...|||...:||
Zfish   300 ----AASYIQGQF-ETKNRSPNKEIYC--HLTCATDTGNIQVVFDAVTDIIIANNLR 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	150/336 (45%)
gnao1b	NP_957122.1	G_alpha	14..352	CDD:214595	158/359 (44%)
gnao1b	NP_957122.1	G-alpha	43..348	CDD:206639	144/327 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820