DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and gnai2a

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001001818.1	Gene:	gnai2a / 336421	ZFINID:	ZDB-GENE-030131-8365	Length:	355	Species:	Danio rerio

Alignment Length:	394	Identity:	158/394 - (40%)
Similarity:	214/394 - (54%)	Gaps:	58/394 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||         .|:.|| |:...||..|.|.|::|.:......:||||||||||||||||||:|
Zfish     1 MGC---------TVSQED-KAALERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFN- 129
            :|.||:|:.|.||....:..|...:|:.|..||::|             ::|| :|.|.:.|..
Zfish    56 IHEDGYSEEECKQYRAVVFSNTIQSIMAIVKAMTSL-------------KIEY-EDSARADDARQ 106

  Fly   130 -------------YPPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPN 181
                         .|.|.......||.|:||...:.|:.||||.|.|.|:|:.:..|...:|.|.
Zfish   107 LFALSGTAEEQGILPDELANVICRLWADRGVQNCFTRAREYQLNDSAAYYLNDMERIAKADYIPT 171

  Fly   182 EQDILRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLR 246
            :||:||.||.|:||.||.|....::|.||||||||.||:|||.||..||||||..|.|:|::||.
Zfish   172 QQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVAMSAYDLVLA 236

  Fly   247 EDPTQNRLRESLDLFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPID 311
            ||...||:.||:.||.||.||:|....||||||||:||..:||.  :|.|...|.|:
Zfish   237 EDEEMNRMHESMKLFDSICNNKWFTETSIILFLNKKDLFEQKIT--RSSLIICFPEY-------- 291

  Fly   312 TGDAIMESNDDPEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQR 376
                  ...|:.|  .|..:||.:|..::......:  .|||||||.||:|::.||:...|:|.:
Zfish   292 ------PGEDNYE--EASEYIRTKFEDLNKKKETKE--IYPHFTCATDTKNVQFVFDAVTDVIIK 346

  Fly   377 MHLR 380
            .:|:
Zfish   347 NNLK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	144/348 (41%)
gnai2a	NP_001001818.1	G_alpha	14..353	CDD:214595	151/371 (41%)
gnai2a	NP_001001818.1	G-alpha	34..349	CDD:206639	144/348 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820