Protein Alignment Galphas and GNAI3

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_006487.1
• Gene: GNAI3 / 2773
• HGNCID: 4387
• Length: 354
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 158/381 - (41%)
• Similarity: 215/381 - (56%)
• Gaps: 31/381 - (8%)

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||         .:::|| |:...||..|.|.|::|.:......:||||||||||||||||||:|
Human     1 MGC---------TLSAED-KAAVERSKMIDRNLREDGEKAAKEVKLLLLGAGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130
            :|.||:|:.|.||....:..|...:|:.|..||..|........:.::.|..::. ..|:.:...
Human    56 IHEDGYSEDECKQYKVVVYSNTIQSIIAIIRAMGRLKIDFGEAARADDARQLFVL-AGSAEEGVM 119

  Fly   131 PPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGI 195
            .||.....:.||:|.||...:.||.||||.|.|.|:|:.:..|...||.|.:||:||.||.|:||
Human   120 TPELAGVIKRLWRDGGVQACFSRSREYQLNDSASYYLNDLDRISQSNYIPTQQDVLRTRVKTTGI 184

  Fly   196 FETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDL 260
            .||.|....:.|.||||||||.||:|||.||..||||||..|.|.|::||.||...||:.||:.|
Human   185 VETHFTFKDLYFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKL 249

  Fly   261 FKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEV 325
            |.||.||:|....||||||||:||..||||  :|.|:..:.|:        ||....|
Human   250 FDSICNNKWFTETSIILFLNKKDLFEEKIK--RSPLTICYPEY--------TGSNTYE------- 297

  Fly   326 IRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQ 381
             .|..:|:.:|..::... |.|. .|.|||||.||:|::.||:...|:|.:.:|::
Human   298 -EAAAYIQCQFEDLNRRK-DTKE-IYTHFTCATDTKNVQFVFDAVTDVIIKNNLKE 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	145/334 (43%)
GNAI3	NP_006487.1	G-alpha	34..348	CDD:206639	145/334 (43%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	173..181		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	196..205		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	265..272		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	324..329		3/4 (75%)