DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and GNAI2

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_002061.1	Gene:	GNAI2 / 2771	HGNCID:	4385	Length:	355	Species:	Homo sapiens

Alignment Length:	383	Identity:	155/383 - (40%)
Similarity:	210/383 - (54%)	Gaps:	36/383 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGCFGSPTSKQSDVNSEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRI 65
            |||         .|::|| |:...||..|.:.|::|.:......:||||||||||||||||||:|
Human     1 MGC---------TVSAED-KAAAERSKMIDKNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKI 55

  Fly    66 LHVDGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNY 130
            :|.||:|:.|.:|....:..|...:|:.|..||..|....|...:.::.|..:.....:......
Human    56 IHEDGYSEEECRQYRAVVYSNTIQSIMAIVKAMGNLQIDFADPSRADDARQLFALSCTAEEQGVL 120

  Fly   131 PPEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGI 195
            |.:.......||.|.||...:.||.||||.|.|.|:|:.:..|...:|.|.:||:||.||.|:||
Human   121 PDDLSGVIRRLWADHGVQACFGRSREYQLNDSAAYYLNDLERIAQSDYIPTQQDVLRTRVKTTGI 185

  Fly   196 FETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDL 260
            .||.|....::|.||||||||.||:|||.||..||||||..|.|:|::||.||...||:.||:.|
Human   186 VETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSAYDLVLAEDEEMNRMHESMKL 250

  Fly   261 FKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEF---NKYQTPIDTGDAIMESNDD 322
            |.||.||:|....||||||||:||..|||.  .|.|:..|.|:   |||.
Human   251 FDSICNNKWFTDTSIILFLNKKDLFEEKIT--HSPLTICFPEYTGANKYD--------------- 298

  Fly   323 PEVIRAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380
                .|..:|:.:|..::... |.|. .|.|||||.||:|::.||:...|:|.:.:|:
Human   299 ----EAASYIQSKFEDLNKRK-DTKE-IYTHFTCATDTKNVQFVFDAVTDVIIKNNLK 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	142/337 (42%)
GNAI2	NP_002061.1	G-alpha	34..349	CDD:206639	142/337 (42%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	35..48		11/12 (92%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	174..182		5/7 (71%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	197..206		7/8 (88%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	266..273		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	325..330		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820