DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and GNA15

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_002059.3	Gene:	GNA15 / 2769	HGNCID:	4383	Length:	374	Species:	Homo sapiens

Alignment Length:	389	Identity:	143/389 - (36%)
Similarity:	206/389 - (52%)	Gaps:	48/389 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SEDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKI 80
            :||.|:..|....|:|.|.:.|:..|...:|||||.|||||||.:|||||:|..|:|:.|:|...
Human    15 TEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFR 79

  Fly    81 DDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQD----------YASSPDFNYPPEFY 135
            ..:.:||..::..:..||..|..|.:..:.::...:...||          ||::..:
Human    80 PLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQDPYKVTTFEKRYAAAMQW------- 137

  Fly   136 EHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRF 200
                 ||:|.|:...|||..|:.|:|.|.|:|..:..|....|.|..||:||.|:.|:||.|..|
Human   138 -----LWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCF 197

  Fly   201 QVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIW 265
            .|.|.|..:.|||||:.||:|||.||.:|.|:|::.:.|.|:..|.|:..:||::|||.||.:|.
Human   198 SVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTIL 262

  Fly   266 NNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKY 330
            ...|.::.|:||||||.|:|.|||..  |.|:.||..|   |.|....:|            ||.
Human   263 ELPWFKSTSVILFLNKTDILEEKIPT--SHLATYFPSF---QGPKQDAEA------------AKR 310

  Fly   331 FIRDEFLRISTASGDG---------KHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            ||.|.:.|:.|...||         ....:.|:|||.||:||::||.|.||.:...:|.:..||
Human   311 FILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	131/353 (37%)
GNA15	NP_002059.3	G_alpha	22..372	CDD:214595	138/378 (37%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	44..57		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	181..189		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	204..213		4/8 (50%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	273..280		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	344..349		3/4 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820