DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphas and GNA12

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_031379.2	Gene:	GNA12 / 2768	HGNCID:	4380	Length:	381	Species:	Homo sapiens

Alignment Length:	390	Identity:	133/390 - (34%)
Similarity:	203/390 - (52%)	Gaps:	37/390 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GSPTSKQSDVNSEDSKSQ-KRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHV 68
            |....:::...:.|::.: :|||..|...|.::::..|...::||||||||||||.:|||||:|.
Human    18 GGARERRAGSGARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHG 82

  Fly    69 DGFSDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPE 133
            ..|......:..|.|..||......:..|...|..|  .:..|||....::..:.:.......|.
Human    83 REFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIP--WQYSENEKHGMFLMAFENKAGLPVEPA 145

  Fly   134 FYE----HTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSG 194
            .::    ....||:|.|:.:.:.|.:|:||.:..|||||.:..|...||.|::||||..|..|.|
Human   146 TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKG 210

  Fly   195 IFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLD 259
            |.|..|.:.|:.|.|.||||||.:|:||.|||:.:|:|:|:.:.|.|:.||.||...|||.||::
Human   211 IVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMN 275

  Fly   260 LFKSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPE 324
            :|::|.||:....:||||||||.|||.||:|.  ..:.::|.:|                ..||.
Human   276 IFETIVNNKLFFNVSIILFLNKMDLLVEKVKT--VSIKKHFPDF----------------RGDPH 322

  Fly   325 VIRAKYFIRDEFLRISTASGDGKHY-----CYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384
            .:       ::..|......|.|..     .:.|||.|:||||::.||:..:|.|.:.:|:...|
Human   323 RL-------EDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENVRFVFHAVKDTILQENLKDIML 380

Fly 385 384
Human 381 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	123/343 (36%)
GNA12	NP_031379.2	G_alpha	42..379	CDD:214595	127/363 (35%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	59..72		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	200..208		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	223..232		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	292..299		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	351..356		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820