DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and Gnal

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_001178765.1	Gene:	Gnal / 24611	RGDID:	2715	Length:	450	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	261/379 - (68%)
Similarity:	312/379 - (82%)	Gaps:	6/379 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KQSDVNSED---SKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGF 71
            :|..:.:|:   :|..::.|..|.|.|::.|:..:.||||||||||||||||||||||||||:||
  Rat    75 RQEQLRAEEREAAKEARKVSRGIDRMLREQKRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNGF 139

  Fly    72 SDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYE 136
            :..||||||.||:||::|||:||..||||:.|||.|...||:.|.:||:..|...||.|..||::
  Rat   140 NPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFD 204

  Fly   137 HTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQ 201
            |.::||.|:||...:||||||||||||:|||:|:.::...:|||.:||:||||||||||||||||
  Rat   205 HVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQ 269

  Fly   202 VDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWN 266
            ||||||||||||||||||||||||||||||||:|.||||||||:|||...||||||||||:||||
  Rat   270 VDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWN 334

  Fly   267 NRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYF 331
            |||||||||||||||||:||||:.|||||:.:||.|:..|..|   .||..::.:||:|.|||:|
  Rat   335 NRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVP---EDATPDAGEDPKVTRAKFF 396

  Fly   332 IRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            |||.|||||||:||||||||||||||||||||:|||||||||||||||:|||||
  Rat   397 IRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	245/334 (73%)
Gnal	NP_001178765.1	G_alpha	93..447	CDD:214595	253/356 (71%)
Gnal	NP_001178765.1	G-alpha	112..444	CDD:206639	245/334 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	519	1.000	Domainoid score	I297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	552	1.000	Inparanoid score	I1085
OMA	1	1.010	-	-		QHG48884
OrthoDB	1	1.010	-	-		D325067at33208
OrthoFinder	1	1.000	-	-		FOG0004018
OrthoInspector	1	1.000	-	-		otm44542
orthoMCL	1	0.900	-	-		OOG6_106085
Panther	1	1.100	-	-	O	PTHR10218
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980