Protein Alignment Galphas and Gnaz

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_034441.1
• Gene: Gnaz / 14687
• MGIID: 95780
• Length: 355
• Species: Mus musculus
• Alignment Length: 722
• Identity: 147/722 - (20%)
• Similarity: 240/722 - (33%)
• Gaps: 218/722 - (30%)

  Fly   472 DDFESNLNASTEQL--DDGEPP------------FRKAGQFD--PYSDDPRLAVKKVQLCPQTGT 520
            ||.:|||.....:|  ..|:|.            .|...::|  |:..:...|:||  |..:.|.
Mouse    60 DDLDSNLRKLNSRLFVVRGQPANVFPRLFKEWKISRLTFEYDSEPFGKERDAAIKK--LAMEAGV 122

  Fly   521 LVIAGTA------GNVVMAN----------FEA------SPQVAEETQSNGPLKMTTMNLVSDRD 563
            .||..|:      ..::..|          |:.      .|::..||.||. :....:..||:..
Mouse   123 EVIVKTSHTLYNLDKIIELNGGQPPLTYKRFQTLISRMDPPEMPVETLSNS-IMGCCVTPVSEDH 186

  Fly   564 GFVWKGHDQLKVKRQLLEENSPIIEGVNFLGVLQVLPPAAITCIAMQSKWSLVAAGTAHGLVLFD 628
            |      |:..|..  |||....|||:          |:|:        |   ..|....|...:
Mouse   187 G------DKYGVPS--LEELGFDIEGL----------PSAV--------W---PGGETEALTRIE 222

  Fly   629 --YQNQAPV--LHKCTLNPNDLTGAGETLS----------RRKSFKKTLRESFRRLRKGRSTRNN 679
              .:.:|.|  ..:..:|.|.|..:...||          |...||  |.:.:|:::|   |...
Mouse   223 RHLERKAWVANFERPRMNANSLLASPTGLSPYLRFGCLSCRLFYFK--LTDLYRKVKK---TSTP 282

  Fly   680 P-NAGGAGAGGQHQQSAAETRPVERQIEARPVDDGMGSMVRCLTFAQTFITNQNVYIPTLWSGTN 743
            | :..|.....:...:||.|.|...::|..|:         |            |.||  |.
Mouse   283 PLSLYGQLLWREFFYTAATTNPRFDKMEGNPI---------C------------VRIP--WD--- 321

  Fly   744 SSTVSVFVLNLPPKQPAATAAAGENGADESAQTATATPRGPPVTGKLGKEIQMKHRAPIIGIAVV 808
                         |.|.|.|        :.|:..|..|....:..:|.:|..:.|.|. ..:|..
Mouse   322 -------------KNPEALA--------KWAEAKTGFPWIDAIMTQLRQEGWIHHLAR-HAVACF 364

  Fly   809 DSNGVPLEFQNVPGPAPHRVLIASEEQFKIFSLPQLKPVNKYKLTAHEGARVRRIAF--ATFMCT 871
            .:.|              .:.|:.||..|:|.  :|.....:.:.|.....:...:|  ..|.|.
Mouse   365 LTRG--------------DLWISWEEGMKVFE--ELLLDADWSVNAGSWMWLSCSSFFQQFFHCY 413

  Fly   872 VPTSSLVNSSPPKALVK---PASPAAPAQQAADPPTTAADNNTSTTAVNDNNTSIVG----SDVT 929
            .|......:.|....::   |.....||:...| |..|.|      :|......|:|    ..:.
Mouse   414 CPVGFGRRTDPNGDFIRRYLPILRGFPAKYIYD-PWNAPD------SVQAAAKCIIGVHYPKPMV 471

  Fly   930 THYEISLLCLTNLGDCLVLTVPELRRQLNSAAVRREDINGISSLCFTSHGEALYMMSSSEVQRIS 994
            .|.|.|.|.:            |..:|:.....|...:..::|:..|.:|....|..|...|:
Mouse   472 NHAEASRLNI------------ERMKQIYQQLSRYRGLGLLASVPSTHNGNGNGMAYSPGEQQ-- 522

  Fly   995 LSATKIVAP------------NGMI----DVEDWSAPIDGASTEEDNEQQDQQAQETMQAEAASQ 1043
             |.|...||            :|.|    |.|:...|   :..::.::||.||.|   |.:....
Mouse   523 -SGTNTPAPAVSSGSVASGNRSGSILLNFDSEEHQGP---SGIQQQHQQQQQQQQ---QQQLGYH 580

  Fly  1044 QEPDDNASGSVAAAKSEQSVSREKVSGSATLLTNGAS----NPRLSNGVASGDEASPNKANETIT 1104
            ..||...:...    .:.:||.:..:|.  ||..|.|    ..|.|.....|::.|.:.::: :.
Mouse   581 HMPDSGHNSRF----YKSNVSHDMAAGH--LLHKGGSVTGKRERESERDLDGEDESLSTSHK-LQ 638

  Fly  1105 SSIGDIT 1111
            ..|.::|
Mouse   639 RQIAEVT 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639
Gnaz	NP_034441.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		G-alpha	34..349	CDD:206639	77/372 (21%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	35..48
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	174..182		0/7 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	197..206		4/18 (22%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	266..273		3/8 (38%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	325..330		2/12 (17%)