Protein Alignment Galphas and Gnat1

DIOPT Version :10

• Sequence 1: NP_477505.1
• Gene: Galphas / 37805
• FlyBaseID: FBgn0001123
• Length: 385
• Species: Drosophila melanogaster
• Sequence 2: NP_032166.1
• Gene: Gnat1 / 14685
• MGIID: 95778
• Length: 350
• Species: Mus musculus
• Alignment Length: 363
• Identity: 154/363 - (42%)
• Similarity: 222/363 - (61%)
• Gaps: 23/363 - (6%)

  Fly    19 SKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDI 83
            :.::::.|..:.::|::|.:....|.:||||||||||||||||||:|:|.||:|..|..:.|..|
Mouse     5 ASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAII 69

  Fly    84 KKNIRDAILTITGAMSTLNPPVALEKKENEPR-VEYIQDYASSPDFNYPPEFYEHTEELWKDKGV 147
            ..|...:||.|..||:|||.......::::.| :.::.|  :..:...|.|..:..:.||||.|:
Mouse    70 YGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMAD--TIEEGTMPKEMSDIIQRLWKDSGI 132

  Fly   148 LQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMFDV 212
            ...::|::||||.|.|.|:|..:..:..|.|.|.|||:||.||.|:||.||:|....:||.||||
Mouse   133 QACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDV 197

  Fly   213 GGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISIIL 277
            ||||.||:|||.||..||.|||:.|.|:|:|||.||...||:.|||.||.||.|:|:..|.||:|
Mouse   198 GGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVL 262

  Fly   278 FLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRISTA 342
            ||||:|:.:||||  |:.||..|.:::...|..|.|:                :|:.:||.::..
Mouse   263 FLNKKDVFSEKIK--KAHLSICFPDYDGPNTYEDAGN----------------YIKVQFLELNMR 309

  Fly   343 SGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLR 380
            . |.|. .|.|.|||.||:|:|.||:...|||.:.:|:
Mouse   310 R-DVKE-IYSHMTCATDTQNVKFVFDAVTDIIIKENLK 345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_477505.1	G-alpha	44..379	CDD:206639	149/335 (44%)
Gnat1	NP_032166.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/15 (13%)
		G-alpha	30..344	CDD:206639	149/335 (44%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	31..44		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	169..177		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	192..201		7/8 (88%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	261..268		5/6 (83%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	320..325		3/4 (75%)
		Interaction with RHO. /evidence=ECO:0000250|UniProtKB:P04695	340..350		1/6 (17%)