DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and Gnas

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_034439.2	Gene:	Gnas / 14683	MGIID:	95777	Length:	1133	Species:	Mus musculus

Alignment Length:	384	Identity:	268/384 - (69%)
Similarity:	309/384 - (80%)	Gaps:	18/384 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EDSKSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGF---------- 71
            |..::.|:||..|.:||:::|..|..||||||||||||||||||||||||||:||
Mouse   753 EQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQ 817

  Fly    72 -----SDSEKKQKIDDIKKNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYP 131
                 ||.||..|:.|||.|:::||.||..|||.|.|||.|...||:.||:||....:.|:|::|
Mouse   818 AARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFP 882

  Fly   132 PEFYEHTEELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIF 196
            ||||||.:.||:|:||...|||||||||||||:||||::..||..:|.|::||:|||||||||||
Mouse   883 PEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIF 947

  Fly   197 ETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLF 261
            ||:||||||||||||||||||||||||||||||||||||.|.||||||:|||...|||:|:|:||
Mouse   948 ETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLF 1012

  Fly   262 KSIWNNRWLRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVI 326
            |||||||||||||:|||||||||||||:.|||||:.:||.||.:|.||   .||..|..:||.|.
Mouse  1013 KSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTP---EDATPEPGEDPRVT 1074

  Fly   327 RAKYFIRDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYELL 385
            ||||||||||||||||||||:||||||||||||||||:|||||||||||||||||||||
Mouse  1075 RAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL 1133

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	250/349 (72%)
Gnas	NP_034439.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..195
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..552
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..744
		G_alpha	759..1130	CDD:214595	262/373 (70%)
		G-alpha	780..1127	CDD:206639	250/349 (72%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	781..794		12/12 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..828		4/20 (20%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	935..943		6/7 (86%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	958..967		8/8 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	1027..1034		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	1103..1108		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	522	1.000	Domainoid score	I301
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55534
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D325067at33208
OrthoFinder	1	1.000	-	-		FOG0004018
OrthoInspector	1	1.000	-	-		otm42477
orthoMCL	1	0.900	-	-		OOG6_106085
Panther	1	1.100	-	-	LDO	PTHR10218
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3262
SonicParanoid	1	1.000	-	-		X2771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.950