DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Galphas and Gna12

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_034432.1	Gene:	Gna12 / 14673	MGIID:	95767	Length:	379	Species:	Mus musculus

Alignment Length:	374	Identity:	132/374 - (35%)
Similarity:	196/374 - (52%)	Gaps:	36/374 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KSQKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIK 84
            :..:|||..|...|.::::..|...::||||||||||||.:|||||:|...|......:..|.|.
Mouse    32 REARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIF 96

  Fly    85 KNIRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPPEFYE----HTEELWKDK 145
            .||......:..|...|..|  .:..|||....::..:.:.......|..::    ....||:|.
Mouse    97 DNILKGSRVLVDARDKLGIP--WQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDS 159

  Fly   146 GVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDKVNFHMF 210
            |:.:.:.|.:|:||.:..|||||.:..|...||.|::||||..|..|.||.|..|.:.|:.|.|.
Mouse   160 GIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMV 224

  Fly   211 DVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRWLRTISI 275
            ||||||.:|:||.|||:.:|:|:|:.:.|.|:.||.||...|||.||:::|::|.||:....:||
Mouse   225 DVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSI 289

  Fly   276 ILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIRAKYFIRDEFLRIS 340
            ||||||.|||.||:|:  ..:.::|.:|                ..||..:       ::..|..
Mouse   290 ILFLNKMDLLVEKVKS--VSIKKHFPDF----------------KGDPHRL-------EDVQRYL 329

  Fly   341 TASGDGKHY-----CYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384
            ....|.|..     .:.|||.|:|||||:.||:..:|.|.:.:|:...|
Mouse   330 VQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIML 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	124/343 (36%)
Gna12	NP_034432.1	G_alpha	40..377	CDD:214595	128/363 (35%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	57..70		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	198..206		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910