DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Galphas and GNA13

DIOPT Version :9

Sequence 1:	NP_001163283.1	Gene:	Galphas / 37805	FlyBaseID:	FBgn0001123	Length:	385	Species:	Drosophila melanogaster
Sequence 2:	NP_006563.2	Gene:	GNA13 / 10672	HGNCID:	4381	Length:	377	Species:	Homo sapiens

Alignment Length:	377	Identity:	136/377 - (36%)
Similarity:	195/377 - (51%)	Gaps:	41/377 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 QKRRSDAISRQLQKDKQLYRATHRLLLLGAGESGKSTIVKQMRILHVDGFSDSEKKQKIDDIKKN 86
            |:|:|..|.:.|.::|...:...::||||||||||||.:|||||:|...|....:::....|..|
Human    27 QQRKSKEIDKCLSREKTYVKRLVKILLLGAGESGKSTFLKQMRIIHGQDFDQRAREEFRPTIYSN 91

  Fly    87 IRDAILTITGAMSTLNPPVALEKKENEPRVEYIQDYASSPDFNYPP------------EFYEHTE 139
            :...:..:..|...|:.|......:..      .|...|.|...|.            ::.....
Human    92 VIKGMRVLVDAREKLHIPWGDNSNQQH------GDKMMSFDTRAPMAAQGMVETRVFLQYLPAIR 150

  Fly   140 ELWKDKGVLQTYERSNEYQLIDCAKYFLDRVSTIKNPNYTPNEQDILRCRVLTSGIFETRFQVDK 204
            .||.|.|:...|:|..|:||.:..|||||.:..:..|:|.|::||||..|..|.||.|..|::..
Human   151 ALWADSGIQNAYDRRREFQLGESVKYFLDNLDKLGEPDYIPSQQDILLARRPTKGIHEYDFEIKN 215

  Fly   205 VNFHMFDVGGQRDERRKWIQCFNDVTAIIFVTACSSYNMVLREDPTQNRLRESLDLFKSIWNNRW 269
            |.|.|.||||||.||::|.:||:.||:|:|:.:.|.::.||.||...|||.|||::|::|.|||.
Human   216 VPFKMVDVGGQRSERKRWFECFDSVTSILFLVSSSEFDQVLMEDRLTNRLTESLNIFETIVNNRV 280

  Fly   270 LRTISIILFLNKQDLLAEKIKAGKSKLSEYFSEFNKYQTPIDTGDAIMESNDDPEVIR--AKYFI 332
            ...:||||||||.|||.||::.  ..:.:||.||                ..||..:|  .|:.:
Human   281 FSNVSIILFLNKTDLLEEKVQI--VSIKDYFLEF----------------EGDPHCLRDVQKFLV 327

  Fly   333 RDEFLRISTASGDGKHYCYPHFTCAVDTENIKRVFNDCRDIIQRMHLRQYEL 384
              |..|........|. .|.|||.|::||||:.||.|.:|.|...:|:|..|
Human   328 --ECFRNKRRDQQQKP-LYHHFTTAINTENIRLVFRDVKDTILHDNLKQLML 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Galphas	NP_001163283.1	G-alpha	44..379	CDD:206639	127/348 (36%)
GNA13	NP_006563.2	G_alpha	29..375	CDD:214595	134/372 (36%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	50..63		10/12 (83%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	195..203		4/7 (57%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	218..227		6/8 (75%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	287..294		6/6 (100%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01230	347..352		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0082
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D754573at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820