DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3735 and utp25

DIOPT Version :9

Sequence 1:	NP_001286797.1	Gene:	CG3735 / 37803	FlyBaseID:	FBgn0034933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_001008035.1	Gene:	utp25 / 493397	XenbaseID:	XB-GENE-1002187	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	798	Identity:	259/798 - (32%)
Similarity:	408/798 - (51%)	Gaps:	148/798 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RAKPYKKPTPARRNER-------FSKNYSFIQRSKQMEESHRRERMPTAPKQEYEPVAELLPEIQ 66
            |.||.::...:..:::       |.:.:.|.....:.:|:.:..::|.:.:.|....:    |.:
Frog     4 RRKPRREEAGSALSKKQKKHLKEFGEQHPFYDAVSKKQETTQVVQLPESSEDESRSES----EAE 64

  Fly    67 DDVDETEFYKKLITGVNNIPTSDILRSKAEKEEDHVIPVPRKIKPKKEKRSEQLG---------- 121
            .|.:....|.||:..:|.:  ||....:::.||:..:.     :.::|..:|::|
Frog    65 SDPEPVNMYHKLLATLNTV--SDEEEEESDDEEEEALE-----EAEEEDEAEEVGEESEAEDEDN 122

  Fly   122 ------------------------------------------VDLEIYNSFSKRFDFELSTDN-- 142
                                                      .|.:..:.||...:| :..||
Frog   123 EDESDGEGHGQMDELPVEAEKAGDNEEEERAGDPAAEEAGEFTDAKHESKFSLETNF-MDEDNED 186

  Fly   143 --------------------INDLIARKDVKTIKRN-------WSALG--NVRFDIPRLTEDFKE 178
                                :...:..:|:..|..|       |.|||  .|...:|:|
Frog   187 SKDESVPCPTVATEDPFVQHVGRELEEQDISKIGTNPKKASLKWPALGQLGVSSSLPQL------ 245

  Fly   179 PDCSEPKDIASTEDLQKLEV------------KASICANAKLPLTALQSQLFYIANNYQDIYYPH 231
                :|..:....|||||.:            ...:..:.:...|.||.:||.|.|:|:|:::|.
Frog   246 ----QPLKVEKETDLQKLYLHKPLFSTWPKVNSPFLSVDKEQNFTPLQRELFSIMNSYRDLFFPA 306

  Fly   232 RT-HGNAEDIRYVYCLHALNHMLKVRSLILRNNEKVSALAKSQKMSPNEISIPESFRDQGLKRMK 295
            |: ....|:||:|||||||||:||..:.:|.||.:    .:.||...:|    |..|||||.|.|
Frog   307 RSPTAQGEEIRHVYCLHALNHVLKANAQVLNNNSQ----KRDQKPGLDE----EDLRDQGLTRPK 363

  Fly   296 VVFVVPFRESALRIVNILGDLLFGSQDDQARKTSIANYERFLGDYSGNTIYFPKTNPKPMDYEQT 360
            |:.||||||||||||.||..|:    :...||..::|.:||..::.......|....:|.|||..
Frog   364 VLIVVPFRESALRIVQILISLM----EVGGRKVDVSNKKRFKEEFGSEPEDRPPNLKRPEDYEAV 424

  Fly   361 FSGNTDDNFKLGIRFTKKTMSLFSDMNASDMLIASPLGLRMLV---TDKESDFDFLNSIELLIID 422
            |:||.||:|::|:...:|:|.|:|...:||::||||:|||.::   .:|:.|||||:|||:||:|
Frog   425 FAGNIDDHFRIGVAILQKSMRLYSPFYSSDIIIASPVGLRTIIGSEGEKKRDFDFLSSIEVLILD 489

  Fly   423 QAELFLAQNWENLLHSLDHLHLQPQKLPDTNCQRVRTWCLSGASSFYRQTLFFSSHELPEFRAVF 487
            ||:|:|.||||::||.:.||:|||......:..|||.|.||..:.:|||||.|||.:.|:..::|
Frog   490 QADLYLMQNWEHVLHLMAHLNLQPTDSHGVDFSRVRMWNLSNWAKYYRQTLLFSSLQEPQINSIF 554

  Fly   488 NSKCNNYQGKVRDSNLVEHGDIRNVLTPIHQVFRLINCSSVETTFDDRFQYFVKNIMPQFSKPGF 552
            |..|.||.|:|...|:...|.|.:|:..:..||:.:...|:.|..|.||::|...|:||:.....
Frog   555 NKHCFNYCGQVAVRNMPVTGSISHVVVQLPHVFQRLEADSLLTVIDARFEFFTSKILPQYRDAIM 619

  Fly   553 SHCMLYVPSYFDYVRIRNHFKTEMVSFVQINEYTKKEKISRARDIFFHSGASVLLYSERAHFFRR 617
            ||.::|:||||||||:||:||.|.::|..|.|||.:..:||||..|.......||.:||.||::|
Frog   620 SHTLIYIPSYFDYVRLRNYFKKEELNFTHICEYTNRSGVSRARQFFLKGERQFLLVTERFHFYKR 684

  Fly   618 TRIKGIRNLIMYQPPNFPHFYSEIINLMLKTNQNPRDGFGDE--MSVSILYTKYDLLSLSNIVGS 680
            ..:|||||||.|:.|.:||||||:.|:|...::      |:|  .:.::||:|||...|:.:||:
Frog   685 YTLKGIRNLIFYELPTYPHFYSEVCNMMKAWHR------GEEATWTCTVLYSKYDAQRLAAVVGA 743

  Fly   681 ENAAKLTSGQKDSYLFST 698
            |.||::...:|:.:||.|
Frog   744 ERAAQMLQSKKNVHLFVT 761

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3735	NP_001286797.1	UTP25	211..696	CDD:284318	213/490 (43%)
utp25	NP_001008035.1	Promotes p53/TP53 degradation. /evidence=ECO:0000250\|UniProtKB:Q6PEH4	1..198		27/205 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..170		22/176 (13%)
		UTP25	286..759	CDD:369113	213/490 (43%)
		Promotes p53/TP53 degradation. /evidence=ECO:0000250\|UniProtKB:Q6PEH4	581..643		26/61 (43%)
		Represses p53/TP53 degradation. /evidence=ECO:0000250\|UniProtKB:Q6PEH4	644..705		28/60 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	410	1.000	Domainoid score	I680
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6170
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1787
OMA	1	1.010	-	-		QHG54945
OrthoDB	1	1.010	-	-		D212972at33208
OrthoFinder	1	1.000	-	-		FOG0005086
OrthoInspector	1	1.000	-	-		oto102443
Panther	1	1.100	-	-	LDO	PTHR12933
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1620
SonicParanoid	1	1.000	-	-		X3607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110