DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3735 and utp25

DIOPT Version :9

Sequence 1:	NP_001286797.1	Gene:	CG3735 / 37803	FlyBaseID:	FBgn0034933	Length:	700	Species:	Drosophila melanogaster
Sequence 2:	NP_775380.1	Gene:	utp25 / 286787	ZFINID:	ZDB-GENE-021217-2	Length:	753	Species:	Danio rerio

Alignment Length:	793	Identity:	251/793 - (31%)
Similarity:	391/793 - (49%)	Gaps:	144/793 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KQKHSK----NRAKPYKKPTPARRNERFSKNYSFIQRSKQMEESHRRERMPTAPKQEYEPVAELL 62
            |::..|    |..|..||     ..:.|.:.:.|..:..:..|..:..|:|.:| |..||.:
Zfish     3 KRRRCKQEIDNLTKKQKK-----HLKEFGEQHPFHDKVVERPEKTQILRLPDSP-QRPEPDS--- 58

  Fly    63 PEIQDDVDETEFYKKLITGV-----NNIPTSD--------------------------------- 89
             |...|.::...|:||::.:     :::.:.|
Zfish    59 -EDDSDAEQPSAYQKLLSTMIRGDEDDVESEDEESEEEDNEEEAEVEGDSEEEVEDTDVEEGNDA 122

  Fly    90 --ILRSKAEKEEDHVIPVPRKIKPKKEKRSEQLGVDLEIYNSFS--------------------- 131
              :|..|.|:..|.:    :|..|:|.....:...:.|:...|:
Zfish   123 EEVLEDKVEETSDKL----QKKHPEKTNGDVEENEEAEMEGEFTDKKNEAAFCLETNMPAEGEEN 183

  Fly   132 ------------KRFDFELSTDNINDLIARKDVKTIKRNWSALGNVRFDIPRLTEDFKEPDCSEP 184
                        |..:.|||.:.:..:.....||| :..|:.||.::              |..|
Zfish   184 TAQQEQDEDMFVKHQEIELSEEEVGRISQGSKVKT-QVKWAKLGVLQ--------------CMSP 233

  Fly   185 KD----IASTEDLQKLEVKASICAN---------AKLPLTALQSQLFYIANNYQDIYYPHRTH-G 235
            .:    |..........:..::.||         |...:|.||.::..:...|:|:|..:.:. .
Zfish   234 LERFPAIGQASSAPLPPIHKTLEANWHLLNLPFGAATDVTELQKEMLGLMGTYRDLYLANLSPLK 298

  Fly   236 NAEDIRYVYCLHALNHMLKVRSLILRNNEKVSALAKSQKMSPNEISIPESFRDQGLKRMKVVFVV 300
            .|:::|..||||||||:||..|.:||||.|:       |.|.|.   .|.||||||.|.||:.:|
Zfish   299 EAKEVRNAYCLHALNHVLKANSRVLRNNAKL-------KESKNG---DEDFRDQGLTRPKVLILV 353

  Fly   301 PFRESALRIVNILGDLLFGSQDDQARKTSIANYERFLGDYSGNTIYFPKTNPKPMDYEQTFSGNT 365
            |||:.|||:|.....||    :.:.:||..:|.:||..:|...|...|....:|.||...||||.
Zfish   354 PFRDGALRVVQTFMTLL----EPKGKKTDASNKKRFKEEYGEETDEKPPNLQRPDDYHAVFSGNI 414

  Fly   366 DDNFKLGIRFTKKTMSLFSDMNASDMLIASPLGLRMLV---TDKESDFDFLNSIELLIIDQAELF 427
            ||:|::|:...:.:|.|::...:||::|||||.||.::   .:|:.|.|||:||||||:|||::|
Zfish   415 DDHFRIGMSILRHSMRLYAPFYSSDIIIASPLSLRTVLGAEGEKKRDHDFLSSIELLIVDQADVF 479

  Fly   428 LAQNWENLLHSLDHLHLQPQKLPDTNCQRVRTWCLSGASSFYRQTLFFSSHELPEFRAVFNSKCN 492
            |.||||:|||.|:||:|||......:..|||.|.|:..:::|||||.||:.:.|:...:....|:
Zfish   480 LMQNWEHLLHVLEHLNLQPLDSHGVDFSRVRMWNLNNWAAYYRQTLVFSAIQEPQITNILTKHCH 544

  Fly   493 NYQGKVRDSNLVEHGDIRNVLTPIHQVFRLINCSSVETTFDDRFQYFVKNIMPQFSKPGFSHCML 557
            ||:|:|....:.:.|.|..||..:..||::.:..|.... |.|.|:||..|:||:.....|...:
Zfish   545 NYRGQVCSKTIPKIGSICQVLVQLPHVFQMFHSDSFMDQ-DARSQFFVDKILPQYRDSVMSDTFI 608

  Fly   558 YVPSYFDYVRIRNHFKTEMVSFVQINEYTKKEKISRARDIFFHSGASVLLYSERAHFFRRTRIKG 622
            ||.||||.||:||:.|.|.||||.|:||:::.::||||..|.......||:|||.||::|..|||
Zfish   609 YVRSYFDLVRLRNYMKKEDVSFVNISEYSQRSEVSRARHYFQKGEKQFLLFSERFHFYKRHTIKG 673

  Fly   623 IRNLIMYQPPNFPHFYSEIINLMLKTNQNPRDGFGDEMS--VSILYTKYDLLSLSNIVGSENAAK 685
            |.|||.|..|.:||||||:.|::   ....|:| |..:|  .:.||::||:..|:.|.|::.||:
Zfish   674 IHNLIFYGLPTYPHFYSEVCNML---QAGVREG-GASVSFTCTALYSRYDVHRLAAITGADRAAQ 734

  Fly   686 LTSGQKDSYLFST 698
            :...:|.::||.|
Zfish   735 MLQSKKTTHLFIT 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3735	NP_001286797.1	UTP25	211..696	CDD:284318	202/490 (41%)
utp25	NP_775380.1	Promotes p53/TP53 degradation. /evidence=ECO:0000269\|PubMed:23357851	1..189		30/199 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..160		29/170 (17%)
		UTP25	273..745	CDD:284318	202/490 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..402		7/24 (29%)
		Promotes p53/TP53 degradation. /evidence=ECO:0000269\|PubMed:23357851	566..627		23/61 (38%)
		Represses p53/TP53 degradation. /evidence=ECO:0000269\|PubMed:23357851	628..689		31/60 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588239
Domainoid	1	1.000	376	1.000	Domainoid score	I829
eggNOG	1	0.900	-	-		E1_KOG2340
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6170
Inparanoid	1	1.050	382	1.000	Inparanoid score	I2012
OMA	1	1.010	-	-		QHG54945
OrthoDB	1	1.010	-	-		D212972at33208
OrthoFinder	1	1.000	-	-		FOG0005086
OrthoInspector	1	1.000	-	-		oto41419
orthoMCL	1	0.900	-	-		OOG6_102630
Panther	1	1.100	-	-	LDO	PTHR12933
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1620
SonicParanoid	1	1.000	-	-		X3607
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300