Protein Alignment CG3735 and utp25

DIOPT Version :10

• Sequence 1: NP_611851.1
• Gene: CG3735 / 37803
• FlyBaseID: FBgn0034933
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_775380.1
• Gene: utp25 / 286787
• ZFINID: ZDB-GENE-021217-2
• Length: 753
• Species: Danio rerio
• Alignment Length: 793
• Identity: 251/793 - (31%)
• Similarity: 391/793 - (49%)
• Gaps: 144/793 - (18%)

  Fly     2 KQKHSK----NRAKPYKKPTPARRNERFSKNYSFIQRSKQMEESHRRERMPTAPKQEYEPVAELL 62
            |::..|    |..|..||     ..:.|.:.:.|..:..:..|..:..|:|.:| |..||.:
Zfish     3 KRRRCKQEIDNLTKKQKK-----HLKEFGEQHPFHDKVVERPEKTQILRLPDSP-QRPEPDS--- 58

  Fly    63 PEIQDDVDETEFYKKLITGV-----NNIPTSD--------------------------------- 89
             |...|.::...|:||::.:     :::.:.|
Zfish    59 -EDDSDAEQPSAYQKLLSTMIRGDEDDVESEDEESEEEDNEEEAEVEGDSEEEVEDTDVEEGNDA 122

  Fly    90 --ILRSKAEKEEDHVIPVPRKIKPKKEKRSEQLGVDLEIYNSFS--------------------- 131
              :|..|.|:..|.:    :|..|:|.....:...:.|:...|:
Zfish   123 EEVLEDKVEETSDKL----QKKHPEKTNGDVEENEEAEMEGEFTDKKNEAAFCLETNMPAEGEEN 183

  Fly   132 ------------KRFDFELSTDNINDLIARKDVKTIKRNWSALGNVRFDIPRLTEDFKEPDCSEP 184
                        |..:.|||.:.:..:.....||| :..|:.||.::              |..|
Zfish   184 TAQQEQDEDMFVKHQEIELSEEEVGRISQGSKVKT-QVKWAKLGVLQ--------------CMSP 233

  Fly   185 KD----IASTEDLQKLEVKASICAN---------AKLPLTALQSQLFYIANNYQDIYYPHRTH-G 235
            .:    |..........:..::.||         |...:|.||.::..:...|:|:|..:.:. .
Zfish   234 LERFPAIGQASSAPLPPIHKTLEANWHLLNLPFGAATDVTELQKEMLGLMGTYRDLYLANLSPLK 298

  Fly   236 NAEDIRYVYCLHALNHMLKVRSLILRNNEKVSALAKSQKMSPNEISIPESFRDQGLKRMKVVFVV 300
            .|:::|..||||||||:||..|.:||||.|:       |.|.|.   .|.||||||.|.||:.:|
Zfish   299 EAKEVRNAYCLHALNHVLKANSRVLRNNAKL-------KESKNG---DEDFRDQGLTRPKVLILV 353

  Fly   301 PFRESALRIVNILGDLLFGSQDDQARKTSIANYERFLGDYSGNTIYFPKTNPKPMDYEQTFSGNT 365
            |||:.|||:|.....||    :.:.:||..:|.:||..:|...|...|....:|.||...||||.
Zfish   354 PFRDGALRVVQTFMTLL----EPKGKKTDASNKKRFKEEYGEETDEKPPNLQRPDDYHAVFSGNI 414

  Fly   366 DDNFKLGIRFTKKTMSLFSDMNASDMLIASPLGLRMLV---TDKESDFDFLNSIELLIIDQAELF 427
            ||:|::|:...:.:|.|::...:||::|||||.||.::   .:|:.|.|||:||||||:|||::|
Zfish   415 DDHFRIGMSILRHSMRLYAPFYSSDIIIASPLSLRTVLGAEGEKKRDHDFLSSIELLIVDQADVF 479

  Fly   428 LAQNWENLLHSLDHLHLQPQKLPDTNCQRVRTWCLSGASSFYRQTLFFSSHELPEFRAVFNSKCN 492
            |.||||:|||.|:||:|||......:..|||.|.|:..:::|||||.||:.:.|:...:....|:
Zfish   480 LMQNWEHLLHVLEHLNLQPLDSHGVDFSRVRMWNLNNWAAYYRQTLVFSAIQEPQITNILTKHCH 544

  Fly   493 NYQGKVRDSNLVEHGDIRNVLTPIHQVFRLINCSSVETTFDDRFQYFVKNIMPQFSKPGFSHCML 557
            ||:|:|....:.:.|.|..||..:..||::.:..|.... |.|.|:||..|:||:.....|...:
Zfish   545 NYRGQVCSKTIPKIGSICQVLVQLPHVFQMFHSDSFMDQ-DARSQFFVDKILPQYRDSVMSDTFI 608

  Fly   558 YVPSYFDYVRIRNHFKTEMVSFVQINEYTKKEKISRARDIFFHSGASVLLYSERAHFFRRTRIKG 622
            ||.||||.||:||:.|.|.||||.|:||:::.::||||..|.......||:|||.||::|..|||
Zfish   609 YVRSYFDLVRLRNYMKKEDVSFVNISEYSQRSEVSRARHYFQKGEKQFLLFSERFHFYKRHTIKG 673

  Fly   623 IRNLIMYQPPNFPHFYSEIINLMLKTNQNPRDGFGDEMS--VSILYTKYDLLSLSNIVGSENAAK 685
            |.|||.|..|.:||||||:.|::   ....|:| |..:|  .:.||::||:..|:.|.|::.||:
Zfish   674 IHNLIFYGLPTYPHFYSEVCNML---QAGVREG-GASVSFTCTALYSRYDVHRLAAITGADRAAQ 734

  Fly   686 LTSGQKDSYLFST 698
            :...:|.::||.|
Zfish   735 MLQSKKTTHLFIT 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3735	NP_611851.1	UTP25	211..696	CDD:369113	202/490 (41%)
utp25	NP_775380.1	Promotes p53/TP53 degradation. /evidence=ECO:0000269|PubMed:23357851	1..189		30/199 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..160		29/170 (17%)
		UTP25	273..745	CDD:369113	202/490 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..402		7/24 (29%)
		Promotes p53/TP53 degradation. /evidence=ECO:0000269|PubMed:23357851	566..627		23/61 (38%)
		Represses p53/TP53 degradation. /evidence=ECO:0000269|PubMed:23357851	628..689		31/60 (52%)