DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG3735 and UTP25

DIOPT Version :9

Sequence 1:NP_001286797.1 Gene:CG3735 / 37803 FlyBaseID:FBgn0034933 Length:700 Species:Drosophila melanogaster
Sequence 2:NP_055203.4 Gene:UTP25 / 27042 HGNCID:28440 Length:756 Species:Homo sapiens


Alignment Length:776 Identity:267/776 - (34%)
Similarity:406/776 - (52%) Gaps:125/776 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 ERFSKNYS-FIQRSKQMEESHRRERMPTAP------KQEYEPVAELLPEIQDDVD---------- 70
            :|.|::.| .:....:.::.|.|:.....|      ::|.:|....|.|..|..|          
Human     3 KRGSRSQSQLLNTLTKKQKKHLRDFGEEHPFYDRVSRKEAKPQICQLSESSDSSDSESDSESEPQ 67

  Fly    71 ETEFYKKLITGVNNIPTSDILRSKAEKEEDHVIP-----------------------------VP 106
            :...|.:|:..:.|:...:....:.|:|||.::.                             |.
Human    68 QVSGYHRLLATLKNVSEEEEEDEEEEEEEDSIVDDAEMNDEDGGSDVSVEEEMAAESTESPENVA 132

  Fly   107 RKIKPK-KEKRSEQLG---------VDLEIYNSFSKRFDF--ELSTDN-------------INDL 146
            ....|: ||...|..|         .|.:..:.||...:|  |.|.||             :|..
Human   133 LSADPEGKEDGEEPPGTSQTSPEEFTDAKHESLFSLETNFLEEESGDNSSLKASQDPFLQHVNKE 197

  Fly   147 IARKDVKTIKRN--------WSALGNVRFDIP-RLTEDFKEPDCSEPKDIASTEDLQKLEVKASI 202
            :..|.::.:..|        |..||.:.|... :..|.||     .||||    ||:.|.::..:
Human   198 LKEKAIQAVATNPKTTHELKWPILGQLFFSSKFQKLETFK-----PPKDI----DLKSLHLQKPL 253

  Fly   203 CA--------------NAKLPLTALQSQLFYIANNYQDIYYPHRTH-GNAEDIRYVYCLHALNHM 252
            .:              .:..|.|.||.:||.|.|:|:|::||.||. .|.|:||:|||||.:||:
Human   254 ESTWTKTNSQFLSGPQKSSSPFTPLQKELFLIMNSYRDLFYPERTALKNGEEIRHVYCLHVINHI 318

  Fly   253 LKVRSLILRNNEKVSALAKSQKMSPNEISIPESFRDQGLKRMKVVFVVPFRESALRIVNILGDLL 317
            ||..:.:|.||.:    .:|||..   :...:.||||||.|.||:.||||||:|||:|.:...||
Human   319 LKANAQVLGNNSR----RRSQKFG---VGDDDDFRDQGLTRPKVLIVVPFREAALRVVQLFISLL 376

  Fly   318 FGSQDDQARKTSIANYERFLGDYSGNTIYFPKTNPKPMDYEQTFSGNTDDNFKLGIRFTKKTMSL 382
            .|   |..:|..::|.:||.|:|..:....|....:|.|||..|.||.||:|::|:...::::.|
Human   377 EG---DSKKKIIVSNKKRFQGEYGSDPEERPPNLKRPEDYEAVFVGNIDDHFRIGVAILQRSIRL 438

  Fly   383 FSDMNASDMLIASPLGLRMLV---TDKESDFDFLNSIELLIIDQAELFLAQNWENLLHSLDHLHL 444
            ::...:||:|||||||||.::   .:|:.|||||:||||||||||:::|.||||::||.::|::|
Human   439 YAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNL 503

  Fly   445 QPQKLPDTNCQRVRTWCLSGASSFYRQTLFFSSHELPEFRAVFNSKCNNYQGKVRDSNLVEHGDI 509
            .|......:..|||.|.|:..|.:|||||.|.:.:..:..:|||..|.|.||:|...|:...|.|
Human   504 LPLDSHGVDFSRVRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNMQGQVAVRNVPMTGSI 568

  Fly   510 RNVLTPIHQVFRLINCSSVETTFDDRFQYFVKNIMPQFSKPGFSHCMLYVPSYFDYVRIRNHFKT 574
            .:||..:..||:.:...::.:..|.||.:||..|:||:.....||.::|:|||||:||:||:||.
Human   569 SHVLVQLPHVFQRMEAENLASVIDARFNFFVNKILPQYRDAVMSHTLIYIPSYFDFVRLRNYFKK 633

  Fly   575 EMVSFVQINEYTKKEKISRARDIFFHSGASVLLYSERAHFFRRTRIKGIRNLIMYQPPNFPHFYS 639
            |.::|..|.|||:|..:||||..|.......||::||.||::|..||||||||.|:.|.:|||||
Human   634 EELNFTHICEYTQKSGVSRARHFFLQGEKQFLLFTERFHFYKRYTIKGIRNLIFYELPTYPHFYS 698

  Fly   640 EIINLMLKTNQNPRDGFGDE--MSVSILYTKYDLLSLSNIVGSENAAKLTSGQKDSYLFST 698
            ||.|::..||:      |:|  .:.::||:|||...|:.:||.|.||::....|:.:||.|
Human   699 EICNMLRATNR------GEEATWTCTVLYSKYDAQRLAAVVGVERAAQMLQSNKNVHLFIT 753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG3735NP_001286797.1 UTP25 211..696 CDD:284318 213/490 (43%)
UTP25NP_055203.4 Promotes p53/TP53 degradation. /evidence=ECO:0000250|UniProtKB:Q6PEH4 1..185 33/181 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..159 25/155 (16%)
UTP25 276..751 CDD:311053 213/490 (43%)
Promotes p53/TP53 degradation. /evidence=ECO:0000250|UniProtKB:Q6PEH4 573..635 24/61 (39%)
Represses p53/TP53 degradation. /evidence=ECO:0000250|UniProtKB:Q6PEH4 636..697 30/60 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165153176
Domainoid 1 1.000 414 1.000 Domainoid score I673
eggNOG 1 0.900 - - E1_KOG2340
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H6170
Inparanoid 1 1.050 423 1.000 Inparanoid score I1778
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54945
OrthoDB 1 1.010 - - D212972at33208
OrthoFinder 1 1.000 - - FOG0005086
OrthoInspector 1 1.000 - - oto88568
orthoMCL 1 0.900 - - OOG6_102630
Panther 1 1.100 - - LDO PTHR12933
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1620
SonicParanoid 1 1.000 - - X3607
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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