DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2812 and wdr47b

DIOPT Version :9

Sequence 1:	NP_611850.1	Gene:	CG2812 / 37801	FlyBaseID:	FBgn0034931	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_001188350.1	Gene:	wdr47b / 567031	ZFINID:	ZDB-GENE-121114-10	Length:	871	Species:	Danio rerio

Alignment Length:	331	Identity:	177/331 - (53%)
Similarity:	224/331 - (67%)	Gaps:	7/331 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ERPH--FEAVTTLSDSQAIRSVDFHPNGKLYAVGSNSKTFRICQYPALSKLRHGHQAAVYPPSVL 78
            |:|.  |.||.||.|:||:|:|.|||:|.|||:||||||.|:|.||  ..|:...||.|..|.:.
Zfish   543 EKPKSPFIAVQTLEDTQAVRAVAFHPSGMLYAIGSNSKTLRVCTYP--QSLKTSPQAPVKQPDIC 605

  Fly    79 CKRTKHHRGSIYCTCWSRDGELIATGSNDKTIKYMRFNNDTNQLVGHEMELNMHDGTVRDMCFLD 143
            .||.|||:|||||..||..|:|:|||||||.:|.:.||.||....|.::|.:|||||:||:.|::
Zfish   606 FKRIKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNADTCNATGPDLEFSMHDGTIRDLAFME 670

  Fly   144 DSSTKSRLLASGGAGDCKIYITDCGTGTPFQAYSGHTGHILSLYSWNNAMFVSGSQDQTIRFWDL 208
            ...:...:|.|.|||||.||.|||..|....|.|||||||||||:|...|..|||||:|:|||||
Zfish   671 GPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILSLYTWGGWMIASGSQDKTVRFWDL 735

  Fly   209 RVNVSVNTLDNDRKDGGLESSAVTAVCVDPTGRLLVSGHADSSCTLYDIRGNRPIQRFYPHTAEI 273
            ||...|..:.......|   |||.:|.:||:|||:.:|..|..|.||||||.|.:|.:.||::::
Zfish   736 RVPSCVKVVGTTLHGTG---SAVASVAIDPSGRLMATGLEDCRCMLYDIRGGRSVQVYRPHSSDV 797

  Fly   274 RCVRFSPSAYYMLTCSYDNSIRLTDLQGDLAHELSSVVVAEHKDKAITIRWHPTEFSFISTSADK 338
            |.|||||.|:|:||.|||:.:.::||||||...|...|||||.||.|..|||..:.||:|:||||
Zfish   798 RSVRFSPGAHYLLTGSYDSRVMISDLQGDLTKNLPVTVVAEHADKVIQCRWHTRDLSFLSSSADK 862

  Fly   339 TATLWA 344
            |.||||
Zfish   863 TVTLWA 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2812	NP_611850.1	WD40	10..>346	CDD:225201	177/331 (53%)
		WD40	32..344	CDD:238121	165/311 (53%)
		WD40 repeat	34..84	CDD:293791	25/49 (51%)
		WD40 repeat	90..131	CDD:293791	20/40 (50%)
		WD40 repeat	136..177	CDD:293791	17/40 (43%)
		WD40 repeat	185..218	CDD:293791	19/32 (59%)
		WD40 repeat	231..267	CDD:293791	18/35 (51%)
		WD40 repeat	273..312	CDD:293791	20/38 (53%)
		WD40 repeat	319..343	CDD:293791	13/23 (57%)
wdr47b	NP_001188350.1	LisH	9..42	CDD:128913
		CTLH	47..100	CDD:128914
		WD40 repeat	522..554	CDD:293791	5/10 (50%)
		WD40	558..868	CDD:238121	167/314 (53%)
		WD40	558..>867	CDD:225201	166/313 (53%)
		WD40 repeat	563..611	CDD:293791	25/49 (51%)
		WD40 repeat	617..658	CDD:293791	20/40 (50%)
		WD40 repeat	663..704	CDD:293791	17/40 (43%)
		WD40 repeat	711..748	CDD:293791	20/36 (56%)
		WD40 repeat	755..791	CDD:293791	18/35 (51%)
		WD40 repeat	797..837	CDD:293791	21/39 (54%)
		WD40 repeat	843..867	CDD:293791	13/23 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581902
Domainoid	1	1.000	66	1.000	Domainoid score	I9917
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003966
OrthoInspector	1	1.000	-	-		otm24369
orthoMCL	1	0.900	-	-		OOG6_106013
Panther	1	1.100	-	-	O	PTHR19863
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3260
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.840