DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2812 and WDR47

DIOPT Version :9

Sequence 1:	NP_611850.1	Gene:	CG2812 / 37801	FlyBaseID:	FBgn0034931	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	XP_011539331.1	Gene:	WDR47 / 22911	HGNCID:	29141	Length:	929	Species:	Homo sapiens

Alignment Length:	342	Identity:	179/342 - (52%)
Similarity:	227/342 - (66%)	Gaps:	12/342 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LDLRKG---DVERPHFEAVTTLSDSQAIRSVDFHPNGKLYAVGSNSKTFRICQYP-ALSKLRHGH 68
            |...||   |..:..|..:..|.|:||:|:|.|||.|.||||||||||.|:|.|| .:....|
Human   590 LSRSKGEEDDKSKKQFVCINILEDTQAVRAVAFHPAGGLYAVGSNSKTLRVCAYPDVIDPSAH-- 652

  Fly    69 QAAVYPPSVLCKRTKHHRGSIYCTCWSRDGELIATGSNDKTIKYMRFNNDT-NQLV-GHEMELNM 131
             .....|.|..||.|||:|||||..||..|:|:|||||||.:|.:.||.:| |..| |.::|.:|
Human   653 -ETPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSNDKYVKVLPFNAETCNATVSGPDLEFSM 716

  Fly   132 HDGTVRDMCFLDDSSTKSRLLASGGAGDCKIYITDCGTGTPFQAYSGHTGHILSLYSWNNAMFVS 196
            ||||:||:.|::...:...:|.|.|||||.||.|||..|....|.||||||||:||:|:..|..|
Human   717 HDGTIRDLAFMEGPESGGAILISAGAGDCNIYTTDCQRGQGLHALSGHTGHILALYTWSGWMIAS 781

  Fly   197 GSQDQTIRFWDLRVNVSVNTLDNDRKDGGLESSAVTAVCVDPTGRLLVSGHADSSCTLYDIRGNR 261
            ||||:|:|||||||...|..:.......|   |||.:|.|||:||||.:|..||||.||||||.|
Human   782 GSQDKTVRFWDLRVPSCVRVVGTTFHGTG---SAVASVAVDPSGRLLATGQEDSSCMLYDIRGGR 843

  Fly   262 PIQRFYPHTAEIRCVRFSPSAYYMLTCSYDNSIRLTDLQGDLAHELSSVVVAEHKDKAITIRWHP 326
            .:|.::||::::|.|||||.|:|:||.|||..|::|||||||..:|..:||.|||||.|..|||.
Human   844 MVQSYHPHSSDVRSVRFSPGAHYLLTGSYDMKIKVTDLQGDLTKQLPIMVVGEHKDKVIQCRWHT 908

  Fly   327 TEFSFISTSADKTATLW 343
            .:.||:|:|||:|.|||
Human   909 QDLSFLSSSADRTVTLW 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2812	NP_611850.1	WD40	10..>346	CDD:225201	178/340 (52%)
		WD40	32..344	CDD:238121	170/315 (54%)
		WD40 repeat	34..84	CDD:293791	24/50 (48%)
		WD40 repeat	90..131	CDD:293791	21/42 (50%)
		WD40 repeat	136..177	CDD:293791	17/40 (43%)
		WD40 repeat	185..218	CDD:293791	18/32 (56%)
		WD40 repeat	231..267	CDD:293791	22/35 (63%)
		WD40 repeat	273..312	CDD:293791	22/38 (58%)
		WD40 repeat	319..343	CDD:293791	12/23 (52%)
WDR47	XP_011539331.1	LisH_TPL	13..40	CDD:375350
		CTLH	45..102	CDD:128914
		WD40	614..925	CDD:238121	170/316 (54%)
		WD40 repeat	619..667	CDD:293791	24/50 (48%)
		WD40 repeat	673..716	CDD:293791	21/42 (50%)
		WD40 repeat	721..762	CDD:293791	17/40 (43%)
		WD40 repeat	772..806	CDD:293791	17/33 (52%)
		WD40 repeat	813..847	CDD:293791	21/33 (64%)
		WD40 repeat	855..894	CDD:293791	22/38 (58%)
		WD40 repeat	901..925	CDD:293791	12/23 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147999
Domainoid	1	1.000	66	1.000	Domainoid score	I10016
eggNOG	1	0.900	-	-		E1_KOG0641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8984
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003966
OrthoInspector	1	1.000	-	-		oto88722
orthoMCL	1	0.900	-	-		OOG6_106013
Panther	1	1.100	-	-	LDO	PTHR19863
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5796
SonicParanoid	1	1.000	-	-		X3260
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.730