DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and SLC12A6

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001352017.1	Gene:	SLC12A6 / 9990	HGNCID:	10914	Length:	1150	Species:	Homo sapiens

Alignment Length:	1103	Identity:	610/1103 - (55%)
Similarity:	791/1103 - (71%)	Gaps:	90/1103 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IPSEHNGTVHE-----------TKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISS 69
            |..||:..:.:           ..|.:.||.:         .|.||.|::::::|||.:|:.::.
Human    97 ITGEHSQLLDDGHKKARNAYLNNSNYEEGDEY---------FDKNLALFEEEMDTRPKVSSLLNR 152

  Fly    70 IANYENTIPAA---------TDPDAKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAG 125
            :|||.|....|         |:...|| ..:.:|||.:||:|||:|||||||||:||||||||||
Human   153 MANYTNLTQGAKEHEEAENITEGKKKP-TKTPQMGTFMGVYLPCLQNIFGVILFLRLTWVVGTAG 216

  Fly   126 AVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAA 190
            .:..|.|||.|||.||||||||||||||||||||||||||||:||||||||||:.||.|||.|||
Human   217 VLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPEFGGAVGLCFYLGTTFAAA 281

  Fly   191 MYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATV 253
            |||:||:||.|.|:.|.|:||  .|..|::.||.||.|||||..|:.|.|:||:||::|||||::
Human   282 MYILGAIEIFLVYIVPRAAIFHSDDALKESAAMLNNMRVYGTAFLVLMVLVVFIGVRYVNKFASL 346

  Fly   254 ALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC--TKE------DSFLRDIYCP 310
            .|||||:||:|:|.|...:........:|:||.|.|....::.|  |||      .|.|...:|.
Human   347 FLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHIDVCSKTKEINNMTVPSKLWGFFCN 411

  Fly   311 DGK-----CEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFIS--YGKSAIDIENTSGES 368
            ..:     |:||::.||||.::||.|||||:..:|::.::|.||:.|.  ..||: |:..:....
Human   412 SSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEIIEKPSAKSS-DVLGSLNHE 475

  Fly   369 YNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFF 433
            |  ::.|||||||||:||||||||||||||||||||.|||||||||||.||||||.||||:|:.|
Human   476 Y--VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLSNVVLF 538

  Fly   434 AGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEI 498
            ...::.::||||||.::.|.|||..::||:.|||:||||.||.||||||||||||||||||:|.|
Human   539 GACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDNI 603

  Fly   499 IPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLR 563
            ||||..|..|...||||.|||||..|.:.|||:.::||:||:|||||||||.|||||||:|||||
Human   604 IPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFFLMCYLFVNLACALQTLLR 668

  Fly   564 TPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGM 628
            ||||||||::|||:||.:|:::|:::|.::|||:|::||.:|.:|||||||:||||||||||||:
Human   669 TPNWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYKYIEYQGAEKEWGDGIRGL 733

  Fly   629 ALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKG 693
            :|:|||::|||||||||||||||||:|||.||:::|..|:.::.:||:||||||||||..|||.|
Human   734 SLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFASQLKAGKGLTIVGSVIVG 798

  Fly   694 DHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYS 758
            :..:...:|:.|:.|::..|..|||||||.::||.::.||:|.:||:.||||||.|||::|||..
Human   799 NFLENYGEALAAEQTIKHLMEAEKVKGFCQLVVAAKLREGISHLIQSCGLGGMKHNTVVMGWPNG 863

  Fly   759 WRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPF 821
            ||| |...:|||||.|||...|.|:||:|.|.|:|:|.:..:.. ||||:||||||||:||||||
Human   864 WRQSEDARAWKTFIGTVRVTTAAHLALLVAKNISFFPSNVEQFSEGNIDVWWIVHDGGMLMLLPF 928

  Fly   822 LLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLM 886
            |||||:.||.|.:|||||||:|||||||||||.||||||||||:||||||::|||||||||||||
Human   929 LLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEVVEMHDSDISAYTYERTLM 993

  Fly   887 MEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIE 951
            ||||:||||.:.|:|.|..:..|.:.|      .|.|..:.:|.....:.|:          |.:
Human   994 MEQRSQMLRHMRLSKTERDREAQLVKD------RNSMLRLTSIGSDEDEETE----------TYQ 1042

  Fly   952 ETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKS--SVKPDEFNVRRMHTAIK 1014
            |..|.....|                 :..:::.:..:..:| |:.  :::||:.||||||||:|
Human  1043 EKVHMTWTKD-----------------KYMASRGQKAKSMEG-FQDLLNMRPDQSNVRRMHTAVK 1089

  Fly  1015 LNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            ||||||.||.:|:||::|:|||||  ..|.:.||||||||||||||:||:|||||.|||||||
Human  1090 LNEVIVNKSHEAKLVLLNMPGPPR--NPEGDENYMEFLEVLTEGLERVLLVRGGGSEVITIYS 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	601/1057 (57%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	218/406 (54%)
SLC12A6	NP_001352017.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..66
		2a30	109..1150	CDD:273347	605/1089 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..181		4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158224
Domainoid	1	1.000	426	1.000	Domainoid score	I605
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1162	1.000	Inparanoid score	I205
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm41076
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800