Protein Alignment kcc and VHC1

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_009794.3
• Gene: VHC1 / 852537
• SGDID: S000000439
• Length: 1120
• Species: Saccharomyces cerevisiae
• Alignment Length: 1235
• Identity: 297/1235 - (24%)
• Similarity: 489/1235 - (39%)
• Gaps: 324/1235 - (26%)

  Fly    36 HR-----AEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENT-----IPAATDPDAKPAAP 90
            ||     :..|:.||:          |..|....|:.    ||:.|     :.:..|||    .|
Yeast    12 HRPSSAISSSNESSSL----------LSARRISQTYF----NYQATPECQKVSSKYDPD----NP 58

  Fly    91 SA-RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNG 154
            :. ::||..|||:|...|:..:::|:|..:::|..|.:|...::|....:.:||.:|:|||:|||
Yeast    59 NKDKLGTYDGVFVPTALNVLSILMFLRFGFILGQLGIICTIGLLLLSYTINLLTTLSISAISTNG 123

  Fly   155 VVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIV---LTYMA---PWASI--- 210
            .|..||:|:||||||||||||::|::|:.|....|.|..||.:|.:   |.|.|   |.|::
Yeast   124 TVRGGGAYYMISRSLGPEFGGSIGLVFFLGQVFNAGMNAVGIIEPLLYNLGYSAQGEPPAALGEL 188

  Fly   211 -----FGDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIF 270
                 :.:||            |.|::|.....:.|:|.:.|::...:....:..||.:
Yeast   189 LPRGHWHEFT------------YATVILFLCFSVAFVGSQTVSRAGNILFLVLAASIFS------ 235

  Fly   271 DNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASG 335
                                 |||      .:.:|..:...|              ....|.:..
Yeast   236 ---------------------IPL------SALIRSPFTEGG--------------ISYTGPSWQ 259

  Fly   336 VFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNR 400
            .|:||:.| .|.||...|..|..        |::|.           |.|:|||:..||.||:..
Yeast   260 TFHDNLLP-HLTKGAAGSLLKGK--------ETFND-----------LFGVFFPATAGIFAGAGM 304

  Fly   401 SGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQW 465
            |.:|....||||.||:..:|.|...|...|.....::....|.|:.       .::..|: ..||
Yeast   305 SSELRKPSKSIPKGTLWGLLFTFICYAVVVFSMGCSIPRRSLYDEV-------QIIQTIS-SVQW 361

  Fly   466 VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQ-CGI 529
            ||.:|...::|.:.:..:.||..:|:|||:|.|||.|..||.|     |..:|:.|.::.| |
Yeast   362 VIFMGEMATSLFSIIVGMLGAAYVLEAIAKDNIIPGLEIFAHS-----PLYSLIFTWILTQLC-- 419

  Fly   530 LLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTS 594
            |..:|:.:|..::|.|||.:..:||||.:..:...||:||.||:::...:.||..|.:..|::..
Yeast   420 LFSDVNKIATFITMTFLMTFVVMNLACFLLGISSAPNFRPSFKYFNRYTTAIGALLSVVAMLIVD 484

  Fly   595 WYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSK 659
            ...|.:.....|:::.:|.|....|.|||..:.:.....|..||||.:  .:.|.||||||:..
Yeast   485 GISASVLFLAMILLFLFIHYFSPPKSWGDVSQSLIYHQVRKYLLRLRQ--DNIKYWRPQILLFV- 546

  Fly   660 LNDNLLPKYRKIFSFATQLKAGKGLTICVSV-IKGDHTKITNKAVDAKATLRKYMTDEKVKGFCD 723
              ||....: .:..|...||.| ||.|...| :..|..|..|:....:....|......:|.|..
Yeast   547 --DNPRTSW-NLIRFCNHLKKG-GLYILGHVAVTADFPKQLNELKTQQKAWMKIRDMAAIKAFVQ 607

  Fly   724 VLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGW----------PYSWRQ----------------- 761
            |.....:..|:.:|....||||||||..::|:          |.|..|
Yeast   608 VGTGPSLIWGIRNVFIGSGLGGMKPNITVVGFFDLESYRKHIPQSRSQNNLQKQVEIKATVPRST 672

  Fly   762 -------------EGRNSWKT----FIQTVR-------TVAACH--MALMVP---------KGIN 791
                         |.:|..|.    ::|.|.       .:|..|  ..|.:|         |.|:
Yeast   673 CSDVKINVPLPTDECKNETKVNVQQWVQIVEDLSLMQSNIAIAHGFKNLEIPNKRDSCFPKKTID 737

  Fly   792 FYP-----------ESNHKIGGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDN 845
            .||           :....|..|.|.:.::     |.|...|:......|...||:....:.|.:
Yeast   738 LYPIQMCGKVEAKGDQPAAITTNFDTYTLI-----LQLAAILVTVPEWKRTHSLRVILFVEQEYH 797

  Fly   846 SIQMKKDLKTFLYHLRIEADVEVVEMN-------------------NSDISAYTYERTLMMEQRN 891
            .....:.:|..|..|||:|:|.||.::                   ||.::...:.:.| :|.|:
Yeast   798 RTNETQRMKKLLQVLRIDAEVLVVSLDQFRVYNTIVKGDPIVFDYVNSKLADNEWWKDL-VEARD 861

  Fly   892 QM---------------------------LRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTI 929
            .:                           ::.||::...|:::....:|   ||.:::.|.:.|.
Yeast   862 TLKPKRRFSTIEPQTIAKQFTQSRKYTSGVQKLGVSFTMNTRMPTNRID---TPCESEDSDLDTD 923

  Fly   930 VDHHYDA----------------TKTAS-------KVRFADPTIEETQHHDSQNDEKRNSIDLDG 971
            :....||                :||.|       |...:|.:.:..:...|.|...|..:..||
Yeast   924 LTSIRDAFSASTNISVGKDLTTKSKTGSDRTNLLVKNLQSDVSTQSLRPVFSSNTLPRTRVVEDG 988

  Fly   972 PENADT------PETTSNKDESTEKADGD-FKSSVKPD-------EFNVRRMH---------TA- 1012
            .....|      |:.::.....:...:|: .|..|.|:       :..|..|.         ||
Yeast   989 TGEQPTLIPIAEPDLSNGNGTGSGIGNGNKLKKPVLPELSPCCSKDSLVTAMQNLGFNDLPSTAQ 1053

  Fly  1013 -IKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERN--YMEFLEVLTEGLEKVLMVRGGGREVIT 1074
             :.||:|:.:.|:.:.|:...||.|......:.:.:  |:|.|::..|||...:::......|.|
Yeast  1054 HLVLNDVMTQMSKSSDLIFSTLPVPALGTHEDHDASLQYVEDLDIWLEGLPPCMLINSQTMTVTT 1118

  Fly  1075  1074
            Yeast  1119  1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	292/1217 (24%)
VHC1	NP_009794.3	AA_permease_2	45..824	CDD:459263	235/888 (26%)