DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kcc and SLC12A8

DIOPT Version :9

Sequence 1:NP_001286795.1 Gene:kcc / 37800 FlyBaseID:FBgn0261794 Length:1077 Species:Drosophila melanogaster
Sequence 2:NP_001182412.2 Gene:SLC12A8 / 84561 HGNCID:15595 Length:714 Species:Homo sapiens


Alignment Length:801 Identity:170/801 - (21%)
Similarity:275/801 - (34%) Gaps:324/801 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 GTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAG 159
            ||..|||..|:.|||||:||:|..|:||..|.:.|..:|.....|.::|.:|...:.....:.:|
Human    40 GTWDGVFTSCMINIFGVVLFLRTGWLVGNTGVLLGMFLVSFVILVALVTVLSGIGVGERSSIGSG 104

  Fly   160 GSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNN 224
            |.|.|||..||.:.||.:|:|:..|..:|.||||.|               |.:...|...:.|.
Human   105 GVYSMISSVLGGQTGGTIGLLYVFGQCVAGAMYITG---------------FAESISDLLGLGNI 154

  Fly   225 FRVYGTLLLIFMGL--IVFLGVKFVNKFATVALACVILSIIAVYVGIFDNI---HGNEKLYMCVL 284
            :.|.|..:.:.:.|  |...|||::.:...:.|..:.:|.:...||.|.::   ||       .:
Human   155 WAVRGISVAVLLALLGINLAGVKWIIRLQLLLLFLLAVSTLDFVVGSFTHLDPEHG-------FI 212

  Fly   285 GKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
            |                      |.|:                        :..:|..|.:    
Human   213 G----------------------YSPE------------------------LLQNNTLPDY---- 227

  Fly   350 QFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIG 414
                          :.|||:          || :.|:|||:.||:|||.|..|||.:...|||:|
Human   228 --------------SPGESF----------FT-VFGVFFPAATGVMAGFNMGGDLREPAASIPLG 267

  Fly   415 TICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAG 479
            ::.|:..:..:|:..|...........||..|       |:...::... ::.|:|.::|:|.:.
Human   268 SLAAVGISWFLYIIFVFLLGAICTREALRYDF-------LIAEKVSLMG-FLFLLGLYISSLASC 324

  Fly   480 LQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGE-PTRALLLTIVICQCGILLGNVDLLAPLLSM 543
            :..|.||||:||.||::::||.||...:.....: |..|:.||.::....:.:|.|::|||::::
Human   325 MGGLYGAPRILQCIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTI 389

  Fly   544 FFLMCY---------------------------GFVNLACAVQTLL------------------- 562
            .|::.|                           |...|.|:...||                   
Human   390 NFMLTYVAVDYSYFSLSMCSCSLTPVPEPVLREGAEGLHCSEHLLLEKAPSYGSEGPAQRVLEGT 454

  Fly   563 -----------------------------RTPN-------------------------------- 566
                                         |||.                                
Human   455 LLEFTKDMDQLLQLTRKLESSQPRQGEGNRTPESQKRKSKKATKQTLQDSFLLDLKSPPSFPVEI 519

  Fly   567 --------------------------------------------------------------WRP 569
                                                                          ||.
Human   520 SDRLPAASWEGQESCWNKQTSKSEGTQPEGTYGEQLVPELCNQSESSGEDFFLKSRLQEQDVWRR 584

  Fly   570 RFKFY-H----WSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMA 629
            ...|| |    | :||:|....:.:|.:..|.:.|:.||:|.|:|.||         |....|:.
Human   585 STSFYTHMCNPW-VSLLGAVGSLLIMFVIQWVYTLVNMGVAAIVYFYI---------GRASPGLH 639

  Fly   630 L-TAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKG 693
            | :|:.:|..|          |         :...|||..|.:.|...|      :.:..|:.|.
Human   640 LGSASNFSFFR----------W---------MRSLLLPSCRSLRSPQEQ------IILAPSLAKV 679

  Fly   694 D--HTKITNKAVDAKATLRKY 712
            |  .|::|.:..|. ||..:|
Human   680 DMEMTQLTQENADF-ATRDRY 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kccNP_001286795.1 2a30 49..1077 CDD:273347 170/801 (21%)
SLC12 674..1077 CDD:281515 10/41 (24%)
SLC12A8NP_001182412.2 2a30 35..>407 CDD:273347 121/471 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..503 3/31 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..550 0/19 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2083
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.