DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and CCC1

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_174333.2	Gene:	CCC1 / 839924	AraportID:	AT1G30450	Length:	975	Species:	Arabidopsis thaliana

Alignment Length:	1111	Identity:	378/1111 - (34%)
Similarity:	567/1111 - (51%)	Gaps:	220/1111 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EMEII-PSEHNGTVHETKNEDSGDIH---RAEE-----NQKSSIDPNLYLYDDDLETRPHISTFI 67
            ||..| |...:.|:...|....||:.   |..|     :||.|   .|.|:..|
plant    40 EMSSIDPGSSSSTLKNIKVVAPGDVGAGVRGPEDGVNGHQKES---KLELFGFD----------- 90

  Fly    68 SSIANY-------ENTIPAATDP---------DAKPAAPSARMGTLIGVFLPCIQNIFGVILFIR 116
             |:.|.       ...|.|.:.|         ...|..|:.:|||::|||:||:|||.|:|.:||
plant    91 -SLVNILGLKSMTGEQIQAPSSPRDGEDISITQGHPKPPALKMGTMMGVFVPCLQNILGIIYYIR 154

  Fly   117 LTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLF 181
            .||:||.||...|.::|..|...|.||.||:|||||||.:..||.|::|.|:||||.|.::|:.|
plant   155 FTWIVGMAGIGQGLVLVFLCGLCTFLTTISLSAIATNGAMKGGGPYYLIGRALGPEVGISIGLCF 219

  Fly   182 YTGTTLAAAMYIVGAVEIVLTYMAPWASIFGD-FTK-DADAM--------YNNFRVYGTLLLIFM 236
            :.|..:|.|:|::||||..|... |.|.||.: .|| :..|:        .::.:|||.::.|.:
plant   220 FLGNAVAGALYVLGAVETFLKAF-PAAGIFRETITKVNGTAVSESIQSPNSHDLQVYGIVVTILL 283

  Fly   237 GLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKED 301
            ..|||.|||.:|:.|...|..|:|||..:::|||                          ..|.|
plant   284 CFIVFGGVKMINRVAPAFLVPVLLSIFCIFIGIF--------------------------LAKTD 322

  Fly   302 SFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSG 366
            .       ||               .||.||....|.||             :| ||..:.|.:|
plant   323 D-------PD---------------NGITGLRLKSFKDN-------------WG-SAYQMTNDAG 351

  Fly   367 ESYNQIMADIT----TSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYL 427
                  :.|.|    .||..|:|:|||:|||||||||||..|.|.|||||:||:.|.|||:::||
plant   352 ------IPDPTGGTYWSFNELVGLFFPAVTGIMAGSNRSASLKDTQKSIPVGTLAATLTTTSLYL 410

  Fly   428 SSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQA 492
            .||:||..    :..|||.   :..:|:.|.||||...::.:|..||||||.|||||||||||.|
plant   411 ISVLFFGA----VATRDKL---LTDRLLTATIAWPFPAIVHVGIILSTLGAALQSLTGAPRLLAA 468

  Fly   493 IARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACA 557
            ||.|:|:|.|..| |.:...||..|.|.|..||...:::||:||:.|.::||:|:||..|||:|.
plant   469 IANDDILPILNYF-KVADTSEPHIATLFTAFICIGCVVIGNLDLITPTVTMFYLLCYSGVNLSCF 532

  Fly   558 VQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWG 622
            :..||..|:||||:|::|||||.:|.:|||.:|.:.||.|.::|:.:|.:||||:..:|...:||
plant   533 LLDLLDAPSWRPRWKYHHWSLSFVGASLCIVIMFLISWSFTVVAIALASLIYKYVGLKGKAGDWG 597

  Fly   623 DGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVL----SKLNDNLLPKYRKIFSFATQL-KAGK 682
            ||.:......|..||..|.....|.|||.|..||.    .:|.:| :|.:.|:..||..: |.|:
plant   598 DGFKSAYFQLALRSLRSLGANQVHPKNWYPIPLVFCRPWGQLPEN-VPCHPKLADFANCMKKKGR 661

  Fly   683 GLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMK 747
            |::|.||::.||:.:...:|.:|...|..|:..::.:|..:::||..:.||...:|||:|||.:|
plant   662 GMSIFVSILDGDYYECAEEAKEACKQLATYIEYKRCEGVAEIVVAPNMTEGFRGIIQTMGLGNLK 726

  Fly   748 PNTVIIGWPYSWRQEGRNSW-KTFIQTVRTVAACHMALMVPKGINFYPESNHKIGGNIDIWWIVH 811
            ||.|::.:|..||:|..... .||:..:......:.|:::.||::.:|....:..|.||::|||.
plant   727 PNIVVMRYPEIWRRENLTEIPSTFVGIINDCITANKAVVIIKGLDEWPNEYQRQYGTIDLYWIVR 791

  Fly   812 DGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDI 876
            ||||::||..||....::.:||:::|.:|:.:.::..:|.|:|.|||.||:.|:|.||.|.:.||
plant   792 DGGLMLLLSQLLLTKESFESCKIQLFCIAEEDSDAEALKADVKKFLYDLRMHAEVIVVTMKSWDI 856

  Fly   877 SAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTAS 941
                              |:.| |.:|:|.                         ..:||.
plant   857 ------------------RSEG-NSQEDSL-------------------------EAFDAA---- 873

  Fly   942 KVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNV 1006
                      :.:..|...:.||..   ..|..|:......| ::..||.
plant   874 ----------QRRISDYLGEIKRQG---SNPLLANGKPMVVN-EQQVEKF--------------- 909

  Fly  1007 RRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGRE 1071
              ::|.:|||..|:..|:.|.:|:::||.||....|   ..|||::::|.|.:.::|:|||..|:
plant   910 --LYTMLKLNSTILSYSRMAAVVLVSLPPPPLNHPA---YFYMEYMDLLVENVPRMLIVRGYHRD 969

  Fly  1072 VITIYS 1077
            |:|:::
plant   970 VVTLFT 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	365/1063 (34%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	112/404 (28%)
CCC1	NP_174333.2	2a30	56..975	CDD:273347	373/1093 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	72	1.000	Domainoid score	I3327
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	587	1.000	Inparanoid score	I232
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D349744at2759
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		oto3090
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840