Protein Alignment kcc and slc12a5b

DIOPT Version :10

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_009302423.1
• Gene: slc12a5b / 797331
• ZFINID: ZDB-GENE-080707-1
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1123
• Identity: 583/1123 - (51%)
• Similarity: 774/1123 - (68%)
• Gaps: 76/1123 - (6%)

  Fly    18 SEHNGTVHETK---NEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPA 79
            |:.:.|..|:.   |..:.|:.::::..    ..|:.|::::::|.|.:|:.:||:|||.|....
Zfish    17 SQGDATSKESSPFINSSTSDVEKSQQYD----GKNMALFEEEMDTSPMVSSLLSSLANYSNLTQG 77

  Fly    80 ATDPD--------AKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTC 136
            :.:.:        .|.||.:.||||::||:|||:|||.|||||:|:||:||..|.:..|.||..|
Zfish    78 SKEHEEAENNEEARKKAAQAPRMGTIMGVYLPCLQNILGVILFLRMTWLVGVGGVLGTFTIVFMC 142

  Fly   137 CCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVL 201
            |..|||||||||||||||||||||||:|||||||||||||||:.|:.|||.|.||||:|.:||:|
Zfish   143 CSTTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGICFFLGTTFAGAMYILGCIEILL 207

  Fly   202 TYMAPWASIF---GDFTKDAD-AMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSI 262
            .|:.|.|:||   |....:|: |:.||.|||||::|.||.::||:|||:|||.|.|.||||||||
Zfish   208 IYIVPSAAIFKMEGLEGSEAEAALLNNMRVYGTIVLTFMAIVVFVGVKYVNKLALVFLACVILSI 272

  Fly   263 IAVYVGIFDNIHGNEKLYMCVLGKRLL---------KDIPLENCTKEDSFLRDIYCP----DGKC 314
            :|:|.|:...........:||||.|.|         |.|...|.|......|. :|.    :..|
Zfish   273 LAIYAGVIKTSFDPPDFPVCVLGNRTLVSKAYDICAKTIERGNATITTKLWRS-FCDSEFLNATC 336

  Fly   315 EEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFI-SYGKSAI-DIENTSGESYNQIMADIT 377
            :||::.||:::::||.|:.||:..:|:|..::||...: ..|..|: |.|.....|...::||||
Zfish   337 DEYFVNNNISQIQGIPGVTSGILAENLFSGYMEKNSVLEKRGLQAVQDPELPVTNSNRYVLADIT 401

  Fly   378 TSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLL 442
            :.||||:||:|||||||||||||||||.|||||||:|||.||.|||.:|:|||:.|...||.::|
Zfish   402 SFFTLLVGIYFPSVTGIMAGSNRSGDLQDAQKSIPVGTILAITTTSIIYMSSVILFGACVDGVVL 466

  Fly   443 RDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAK 507
            |||||:.:.|.||:..:|||:.|||:.|||.||.||||||||||||||||||||.|||||..|..
Zfish   467 RDKFGEGVSGNLVIGTLAWPSPWVIVFGSFFSTCGAGLQSLTGAPRLLQAIARDGIIPFLRVFGH 531

  Fly   508 SSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFK 572
            ....||||.|||||..||:.|||:.::|.:||:|||||||||.|||||||:||||||||||||||
Zfish   532 GKANGEPTWALLLTACICESGILIASLDAVAPILSMFFLMCYMFVNLACALQTLLRTPNWRPRFK 596

  Fly   573 FYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSL 637
            ||||:|||:|::||:::|.:.|||:|::||.:|..||||||:.||||||||||||::|:|||::|
Zfish   597 FYHWALSLLGMSLCLTLMFLCSWYYAIVAMVIAGCIYKYIEFCGAEKEWGDGIRGISLSAARFAL 661

  Fly   638 LRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKA 702
            :|||||||||||||||||||:.|:.....:..::.|..:||||||||||..:.|:|.:.....|.
Zfish   662 MRLEEGPPHTKNWRPQILVLTTLDGEQNVEQPRLLSLTSQLKAGKGLTIVGACIEGTYLNNQPKT 726

  Fly   703 VDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-EGRNS 766
            ..|..:|||.|..||||||..|:::..:.:..|.:||..||||::.|||::.:|.:|:| |..:.
Zfish   727 QKADQSLRKLMEVEKVKGFSQVVISSNLRDATSHLIQAGGLGGLRHNTVLVSFPKNWKQAEEHHR 791

  Fly   767 WKTFIQTVRTVAACHMALMVPKGINFYPESNHKI-GGNIDIWWIVHDGGLLMLLPFLLKQHRTWR 830
            .:.||:.||...|.||||:|||.|:.||.:..:. .|:||:||||||||:||||||||:||:.||
Zfish   792 CRNFIEVVRETTAGHMALLVPKNISAYPSNGERFTEGHIDVWWIVHDGGMLMLLPFLLRQHKVWR 856

  Fly   831 NCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRNQMLR 895
            .||:|||||||::||||||||||.|||||||::|.||||||.::||||||||:|||||||:|:|:
Zfish   857 KCKMRIFTVAQMDDNSIQMKKDLMTFLYHLRLDAAVEVVEMLDNDISAYTYEKTLMMEQRSQILK 921

  Fly   896 ALGLNKKENSKVVQTIMDY------KETPSD--NKMSLVQTIVDHHYDATKTASKVRFADPTIEE 952
            .:.|.|.|..:.:|:|.|.      ::.||:  .:.|:.:..|....:.......||.:.|  .:
Zfish   922 EMHLTKNEREREIQSITDVSRGSIRRKNPSNLHPQRSIAEESVAGSGEEKPEEESVRVSHP--RQ 984

  Fly   953 TQHHDSQNDEKRNSIDLDGPEN--ADTPETTSNKDE-------STEKADG-------DFKS--SV 999
            .|....:|.....:    .|.:  |.||.|.|..:|       .||||:.       :.|.  ::
Zfish   985 VQLIQGKNATPTPT----SPTSPTAPTPATMSPGEEIQMTWTDDTEKANNPAVANPENIKDMFNM 1045

  Fly  1000 KPD-----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGL 1059
            ||:     :.||||||.|.|||||||:|||:|:||::|:|||||  ....|.|||||||||||||
Zfish  1046 KPEWENLNQSNVRRMHHAQKLNEVIVKKSQEAKLVLLNMPGPPR--NRTGEENYMEFLEVLTEGL 1108

  Fly  1060 EKVLMVRGGGREVITIYS 1077
            .:||:|||||||||||||
Zfish  1109 NRVLLVRGGGREVITIYS 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	AA_permease_2	49..1077	CDD:459263	576/1087 (53%)
slc12a5b	XP_009302423.1	AA_permease_2	24..1126	CDD:459263	579/1114 (52%)