Protein Alignment kcc and slc12a6

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_012820954.1
• Gene: slc12a6 / 780031
• XenbaseID: XB-GENE-960699
• Length: 1133
• Species: Xenopus tropicalis
• Alignment Length: 1104
• Identity: 604/1104 - (54%)
• Similarity: 781/1104 - (70%)
• Gaps: 85/1104 - (7%)

  Fly     5 SAKDDSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISS 69
            |..:::.::..|....:..:::...:|.||          |.|.||.|::::::|||.:|:.::.
 Frog    84 SVTEENSKLLDIDRRKSSVLYQNHTDDEGD----------SYDRNLALFEEEMDTRPKVSSLLNR 138

  Fly    70 IANYENTIPAATDPD-----AKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCG 129
            :|||.|....|.:.:     .|.||.:.||||::||:|||:|||||||||:||.|||||||.:..
 Frog   139 LANYTNLPQGAKEHEEESEGKKKAAKTPRMGTIMGVYLPCLQNIFGVILFLRLPWVVGTAGVLHA 203

  Fly   130 FLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIV 194
            |.||..|||.|||||||||||||||||||||:||||||:||||||||||:.||.|||.|.||||:
 Frog   204 FCIVFACCCCTMLTAISMSAIATNGVVPAGGAYFMISRALGPEFGGAVGLCFYLGTTFATAMYIL 268

  Fly   195 GAVEIVLTYMAPWASIF-GD-FTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALAC 257
            ||:||.|.|::|.|.|| |: ..:::.||.||.|||||..||.|.:|||:||::|||.|:|.|.|
 Frog   269 GAIEIFLVYISPQAVIFHGEGVAEESAAMLNNMRVYGTGFLIIMSIIVFVGVRYVNKLASVFLTC 333

  Fly   258 VILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK---EDSF-----LRDIYCP---- 310
            ||:||:|:|.|...:........:|:||.|.|.......|.|   .|:.     |.:::|.
 Frog   334 VIMSILAIYAGALKSAFSPPDFPICLLGNRTLSKHHFTECAKIVESDNMTIVTDLWNLFCHPSDQ 398

  Fly   311 -DGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAI-DIENTSGESYNQIM 373
             :|.|:||:..||||.|:||.||.||:..:|::.::|:||..|.  |::: ..|..:.:|...::
 Frog   399 LNGTCDEYFAHNNVTLVQGIPGLKSGIISENLWSNYLQKGDIIE--KASLPSTEYLAVQSQEYVL 461

  Fly   374 ADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVD 438
            ||||||||||:||||||||||||||||||||.|||||||||||.||||||.||||:|:.|..::|
 Frog   462 ADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSLVYLSNVILFGASID 526

  Fly   439 NLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLA 503
            .::||||||.::.|.|||..::||:.|||:||||.||.||||||||||||||||||:|.|||||.
 Frog   527 GVVLRDKFGDAVKGTLVVGALSWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIAKDGIIPFLR 591

  Fly   504 PFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWR 568
            .|......||||.|||||.||.:.|||:.::||:||:|||||||||.||||||.:||||.:||||
 Frog   592 VFGHGKSNGEPTWALLLTAVIAELGILIASLDLVAPILSMFFLMCYLFVNLACGLQTLLHSPNWR 656

  Fly   569 PRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAA 633
            |||.:|||:||.:|:.||:::|.::|||:|||:|.:|.:|||||||:||||||||||||::|:||
 Frog   657 PRFHYYHWTLSFLGMALCLALMFISSWYYALISMVIAGMIYKYIEYQGAEKEWGDGIRGLSLSAA 721

  Fly   634 RYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKI 698
            |::|||||||||||||||||:|||.||:.:|.....::.|||:||||||||||..||:.||:.:.
 Frog   722 RFALLRLEEGPPHTKNWRPQLLVLVKLDSDLHVSQPRLLSFASQLKAGKGLTIVGSVLLGDYLEN 786

  Fly   699 TNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-E 762
            ..:|..|:..|:..|..|||||||.|:|||::.||||.:||:.|||||:.||||:.||.|||| :
 Frog   787 HAEAQAAEQALKHLMEQEKVKGFCQVVVAQKLKEGLSHLIQSCGLGGMRHNTVIMSWPSSWRQSD 851

  Fly   763 GRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQH 826
            ...:||:||.|:|...|...||:|.|.::.:|.|...:. |:||:||||||||:|||||||||||
 Frog   852 DSRAWKSFITTIRVTTAARQALLVAKNVSLFPGSREILAEGHIDVWWIVHDGGMLMLLPFLLKQH 916

  Fly   827 RTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRN 891
            :.||.||:|||||||:|||||||||||.||||||||.||||||||::|||||||||||||||||:
 Frog   917 KVWRKCKMRIFTVAQMEDNSIQMKKDLATFLYHLRIAADVEVVEMHDSDISAYTYERTLMMEQRS 981

  Fly   892 QMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADPTIEETQHH 956
            ||||.:.|:|.:..|..|.:.|      .|.|..:.::
 Frog   982 QMLRQMRLSKTDREKEAQLVKD------RNSMLRLTSV--------------------------- 1013

  Fly   957 DSQNDEKRNSIDLDGPENADTPETTSNKDE------STEKADGDFKS--SVKPDEFNVRRMHTAI 1013
            .|.:||...::       .|....|..||:      :..|....|:.  :::||:.||||||||:
 Frog  1014 GSDDDEDTEAV-------PDRVHMTWTKDKHHAVRVAQSKPMPSFQDLLNIRPDQSNVRRMHTAV 1071

  Fly  1014 KLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            |||||||.||.||:||::|:|||||  ..:.:.||||||||||||||.||:|||||.|||||||
 Frog  1072 KLNEVIVNKSHDAKLVLLNMPGPPR--NPQGDENYMEFLEVLTEGLEHVLLVRGGGTEVITIYS 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	595/1058 (56%)
		SLC12	674..1077	CDD:281515	217/412 (53%)
slc12a6	XP_012820954.1	2a30	104..1133	CDD:273347	600/1082 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I592
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1154	1.000	Inparanoid score	I208
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm48284
Panther	1	1.100	-	-	O	PTHR11827
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190