Protein Alignment kcc and slc12a5

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: XP_012808003.1
• Gene: slc12a5 / 779759
• XenbaseID: XB-GENE-483436
• Length: 1105
• Species: Xenopus tropicalis
• Alignment Length: 1124
• Identity: 581/1124 - (51%)
• Similarity: 782/1124 - (69%)
• Gaps: 80/1124 - (7%)

  Fly     9 DSDEMEIIPSEHNGTVHETKNEDSGDIHRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANY 73
            :.:|.|..||:.:|    ...|.|..|:.:|    .....|:.|::::::|.|.:|:.:|.:|||
 Frog     7 ECEEGEGGPSQGDG----NPKESSPFINSSE----MDTGKNMALFEEEMDTSPMVSSLLSGLANY 63

  Fly    74 ENTIPAATDPD--------AKPAAPSARMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGF 130
            .|......:.:        .|....:.||||.:||:|||:|||||||||:|||||||..|.:..|
 Frog    64 TNLTQGVKEHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGVGGIMESF 128

  Fly   131 LIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVG 195
            ::|:.||..|||||||||||||||||||||||:|||||||||||||||:.||.|||.|.||||:|
 Frog   129 IMVVMCCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILG 193

  Fly   196 AVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACV 258
            .:||:|||:.|..:||  .:..::..|:.||.|||||.:|..|.::||:|||:|||||.|.|.||
 Frog   194 TIEILLTYLFPGMAIFIAQEAREEPAALLNNMRVYGTCVLTCMAIVVFVGVKYVNKFALVFLGCV 258

  Fly   259 ILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTK--------EDSFLRDIYCP----D 311
            ||||||:|.|:..:........:|:||.|.|.....:.|.|        ..:.|..::|.    :
 Frog   259 ILSIIAIYAGVIKSAFDPPDFPICLLGNRTLSRKGFDVCAKFIDSGNETVTTKLWALFCSSPFLN 323

  Fly   312 GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKSAI-DIENTSGESYNQ--IM 373
            ..|:.|:..||||:|:||.|:|||:..||::..:::||..:.  |..: ...|:...:.:|  :.
 Frog   324 ATCDTYFSQNNVTEVQGIPGVASGLIRDNLWAGYMQKGIIVE--KQGLRSAPNSDALNLDQPYVF 386

  Fly   374 ADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVD 438
            :|:||.||||:||:|||||||||||||||||.|||||||||||.||.|||.||:|||:.|...::
 Frog   387 SDMTTYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPIGTIMAIATTSFVYISSVILFGACIE 451

  Fly   439 NLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLA 503
            .::||||||:::.|.|||..:|||:.|||:||||.||.||||||||||||||||||||.|:|||.
 Frog   452 GVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVPFLQ 516

  Fly   504 PFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWR 568
            .|......||||.|||||..||:.|||:.::|.:||:|||||||||.||||||||||||||||||
 Frog   517 VFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWR 581

  Fly   569 PRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAA 633
            ||||:|||:||.:|::||:|:|.:.|||:||:||.:|.:||||||||||||||||||||::|:||
 Frog   582 PRFKYYHWTLSFLGMSLCLSLMFICSWYYALVAMSIAGLIYKYIEYRGAEKEWGDGIRGLSLSAA 646

  Fly   634 RYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKI 698
            ||:|||||||||||||||||:|||.:::.:....:.::.|..:||||||||||..||::|.:.:.
 Frog   647 RYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVVEGTYLEN 711

  Fly   699 TNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQ-E 762
            ..:...|:.::|:.|..|||||||.|:::....:|:|.:||:.||||::.||:::|||.:||| |
 Frog   712 HPQCQRAEESIRRLMEAEKVKGFCKVVISSNTRDGISHLIQSSGLGGLQHNTLLVGWPRNWRQKE 776

  Fly   763 GRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GNIDIWWIVHDGGLLMLLPFLLKQH 826
            ...:|:.||:.||...|.|:||:|.|.:..:|.:..:.. ||||:||:|||||:||||||||:.|
 Frog   777 DHQTWRNFIELVRETTAAHLALIVSKNVAMFPGNLERFSEGNIDVWWVVHDGGMLMLLPFLLRHH 841

  Fly   827 RTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEVVEMNNSDISAYTYERTLMMEQRN 891
            :.|:.|.:|||||||::||||||||||.||||||||.|:||||||::|||||||||:||:||||:
 Frog   842 KVWKRCTMRIFTVAQMDDNSIQMKKDLTTFLYHLRINAEVEVVEMHDSDISAYTYEKTLVMEQRS 906

  Fly   892 QMLRALGLNKKENSKVVQTIMD------YKETPSDNKMSL-----------------VQTIVDHH 933
            |:|:.:.|.|.|..:.:|:|.|      .::.||::::.|                 ||.|
 Frog   907 QILKQMHLTKTEREREIQSITDESRGSIRRKNPSNSRLHLSVPEEQVGDCEEKSEEEVQLI---- 967

  Fly   934 YDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSS 998
            :|...|...        |..|....:.|..:..:.|...::..|.|..|:|..||.:|..|| .:
 Frog   968 HDKNTTGFS--------ESAQSPAEEPDTTQEKVHLTWTKDKCTAEKNSSKCPSTPEAIKDF-FN 1023

  Fly   999 VKPD-----EFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEG 1058
            :||:     :.||||||||:|||||||:||.||:||::|:|||||..:.  :.|||||||||||.
 Frog  1024 MKPEWENLNQSNVRRMHTAVKLNEVIVKKSHDAKLVLLNMPGPPRNRKG--DENYMEFLEVLTEH 1086

  Fly  1059 LEKVLMVRGGGREVITIYS 1077
            |::|::|||||||||||||
 Frog  1087 LDRVMLVRGGGREVITIYS 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	570/1082 (53%)
		SLC12	674..1077	CDD:281515	204/432 (47%)
slc12a5	XP_012808003.1	2a30	21..1105	CDD:273347	574/1104 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	429	1.000	Domainoid score	I592
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1154	1.000	Inparanoid score	I208
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm48284
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110