DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and Slc12a6

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001103100.1	Gene:	Slc12a6 / 691209	RGDID:	1311335	Length:	1150	Species:	Rattus norvegicus

Alignment Length:	1121	Identity:	616/1121 - (54%)
Similarity:	796/1121 - (71%)	Gaps:	93/1121 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKDDSDEMEIIPSEHNGTVHETKNEDS---------GDIHRAEENQ----------KSSIDPNLY 51
            |.|.|.:....|.:    |.|..|::|         .|.|:...|.          ....|.||.
  Rat    74 ALDPSSDRTSNPQD----VTEDPNQNSITGEHSQLLDDGHKKARNAYLNNSNYEEGDEYFDKNLA 134

  Fly    52 LYDDDLETRPHISTFISSIANYENTIPAA---------TDPDAKPAAPSARMGTLIGVFLPCIQN 107
            |::::::|||.:|:.::.:|||.|....|         |:...|| ..|.:|||.:||:|||:||
  Rat   135 LFEEEMDTRPKVSSLLNRMANYTNLTQGAKEHEEAENITEGKKKP-TKSPQMGTFMGVYLPCLQN 198

  Fly   108 IFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPE 172
            |||||||:||||||||||.:..|.|||.|||.||||||||||||||||||||||||||||:||||
  Rat   199 IFGVILFLRLTWVVGTAGVLQAFAIVLICCCCTMLTAISMSAIATNGVVPAGGSYFMISRALGPE 263

  Fly   173 FGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLLLIF 235
            ||||||:.||.|||.||||||:||:||.|.|:.|.|:||  .|..|::.||.||.|||||..|:.
  Rat   264 FGGAVGLCFYLGTTFAAAMYILGAIEIFLVYIVPRAAIFRSDDALKESAAMLNNMRVYGTAFLVL 328

  Fly   236 MGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC--T 298
            |.|:||:||::|||||::.|||||:||:|:|.|...:........:|:||.|.|....|:.|  |
  Rat   329 MVLVVFIGVRYVNKFASLFLACVIVSILAIYAGAIKSSFAPPHFPVCMLGNRTLSSRHLDICSKT 393

  Fly   299 KE------DSFLRDIYCPDGK-----CEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFI 352
            ||      .|.|...:|...:     |:||::.||||.::||.|||||:..:|::.::|.||:.|
  Rat   394 KEVNNMTIPSKLWGFFCNSSQFFNATCDEYFVHNNVTSIQGIPGLASGIITENLWSNYLPKGEII 458

  Fly   353 S--YGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGT 415
            .  ..||:..:.|.:.|   .::||||||||||:||||||||||||||||||||.||||||||||
  Rat   459 EKPSAKSSDVLGNLNHE---YVLADITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGT 520

  Fly   416 ICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGAGL 480
            |.||||||.||||:|:.|...::.::||||||.::.|.|||..::||:.|||:||||.||.||||
  Rat   521 ILAILTTSFVYLSNVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWPSPWVIVIGSFFSTCGAGL 585

  Fly   481 QSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFF 545
            ||||||||||||||:|.|||||..|..|...||||.|||||..|.:.|||:.::||:||:|||||
  Rat   586 QSLTGAPRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650

  Fly   546 LMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYK 610
            ||||.|||||||:|||||||:|||||::|||:||.:|:::|:::|.::|||:|::||.:|.:|||
  Rat   651 LMCYLFVNLACALQTLLRTPHWRPRFRYYHWALSFMGMSICLALMFISSWYYAIVAMVIAGMIYK 715

  Fly   611 YIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFSFA 675
            ||||:||||||||||||::|:|||::|||||||||||||||||:|||.||:::|..|:.::.:||
  Rat   716 YIEYQGAEKEWGDGIRGLSLSAARFALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKHPRLLTFA 780

  Fly   676 TQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQT 740
            :||||||||||..|||.|:..:....|:.|:.|::..|..|||||||.::||.::.||:|.:||:
  Rat   781 SQLKAGKGLTIVGSVIVGNFLENYGDALAAEQTIKHLMEAEKVKGFCQLVVAAKLKEGISHLIQS 845

  Fly   741 IGLGGMKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHKIG-GN 803
            .||||||.|||::|||..||| |...:|||||.|||...|.|:||:|.|.::|:|.:..:.. ||
  Rat   846 CGLGGMKHNTVVMGWPNGWRQSEDARAWKTFIGTVRVTTAAHLALLVAKNVSFFPSNVEQFSEGN 910

  Fly   804 IDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEADVEV 868
            ||:||||||||:|||||||||||:.||.|.:|||||||:|||||||||||.||||||||||:|||
  Rat   911 IDVWWIVHDGGMLMLLPFLLKQHKVWRKCSIRIFTVAQLEDNSIQMKKDLATFLYHLRIEAEVEV 975

  Fly   869 VEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHH 933
            |||::|||||||||||||||||:||||.:.|:|.|..:..|.:.|      .|.|..:.:|....
  Rat   976 VEMHDSDISAYTYERTLMMEQRSQMLRHMRLSKTERDREAQLVKD------RNSMLRLTSIGSDE 1034

  Fly   934 YDATKTASKVRFADPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKS- 997
            .:.|:          |.:|..|.....|                 :..:::.:..:..:| |:.
  Rat  1035 DEETE----------TYQEKVHMTWTKD-----------------KYMASRGQKVKSMEG-FQDL 1071

  Fly   998 -SVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEK 1061
             :::||:.||||||||:|||||||.||.:|:||::|:|||||  ..|.:.||||||||||||||:
  Rat  1072 LNMRPDQSNVRRMHTAVKLNEVIVNKSHEAKLVLLNMPGPPR--NPEGDENYMEFLEVLTEGLER 1134

  Fly  1062 VLMVRGGGREVITIYS 1077
            ||:|||||.|||||||
  Rat  1135 VLLVRGGGSEVITIYS 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	602/1057 (57%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	217/406 (53%)
Slc12a6	NP_001103100.1	2a30	109..1150	CDD:273347	605/1080 (56%)
		SLC5-6-like_sbd	209..>360	CDD:294310	105/150 (70%)
		SLC12	774..1150	CDD:281515	217/411 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352205
Domainoid	1	1.000	424	1.000	Domainoid score	I595
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1161	1.000	Inparanoid score	I194
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm45216
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	O	PTHR11827
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770