DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kcc and SLC12A4

DIOPT Version :9

Sequence 1:	NP_001286795.1	Gene:	kcc / 37800	FlyBaseID:	FBgn0261794	Length:	1077	Species:	Drosophila melanogaster
Sequence 2:	NP_001139434.1	Gene:	SLC12A4 / 6560	HGNCID:	10913	Length:	1087	Species:	Homo sapiens

Alignment Length:	1060	Identity:	595/1060 - (56%)
Similarity:	764/1060 - (72%)	Gaps:	68/1060 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PNLYLYDDDLETRPHISTFISSIANYENTIPAATDPD--------AKPAAPSARMGTLIGVFLPC 104
            |:.....::|:.||.:|:.:..:.:|.|....|.:.:        .:.||.:..||||:||:|||
Human    66 PSWMTRTEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGTRRRAAEAPSMGTLMGVYLPC 130

  Fly   105 IQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSYFMISRSL 169
            :|||||||||:||||:|||||.:...||||.|||.|:||||||||||||||||||||||||||||
Human   131 LQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSL 195

  Fly   170 GPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIF--GDFTKDADAMYNNFRVYGTLL 232
            |||||||||:.||.|||.||||||:||:||:|||:||.|:||  ......::|..||.|||||:.
Human   196 GPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGAHDTSNATLNNMRVYGTIF 260

  Fly   233 LIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENC 297
            |.||.|:||:|||:|||||::.|||||:||:::|.|...:|.......:|:||.|.|.....:.|
Human   261 LTFMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDIC 325

  Fly   298 TKE--------DSFLRDIYC--PD---GKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKG 349
            .|.        .:.|...:|  |:   ..|:.|::.||||::.||.|.|:||..:|::.::||||
Human   326 AKTAVVDNETVATQLWSFFCHSPNLTTDSCDPYFMLNNVTEIPGIPGAAAGVLQENLWSAYLEKG 390

  Fly   350 QFI-SYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPI 413
            ..: .:|..:.|..:........::|||.||||:|:||||||||||||||||||||.|||||||:
Human   391 DIVEKHGLPSADAPSLKESLPLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPV 455

  Fly   414 GTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVVANIAWPNQWVILIGSFLSTLGA 478
            |||.||:|||.||.|||:.|...::.::||||:|..:...|||..:|||:.|||:||||.||.||
Human   456 GTILAIITTSLVYFSSVVLFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVIGSFFSTCGA 520

  Fly   479 GLQSLTGAPRLLQAIARDEIIPFLAPFAKSSKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSM 543
            ||||||||||||||||:|.|||||..|......||||.|||||.:|.:.|||:.::|::||:|||
Human   521 GLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKVNGEPTWALLLTALIAELGILIASLDMVAPILSM 585

  Fly   544 FFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIII 608
            ||||||.||||||||||||||||||||||:|||:||.:|::||:::|.::|||:||:||.:|.:|
Human   586 FFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWALSFLGMSLCLALMFVSSWYYALVAMLIAGMI 650

  Fly   609 YKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYRKIFS 673
            ||||||:||||||||||||::|:||||:|||||||||||||||||:|||.||:::|..||.::.:
Human   651 YKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLT 715

  Fly   674 FATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVI 738
            ||:||||||||||..|||:|...:...:|..|:.|::..|..|||||||.|:||.::.|||:.:|
Human   716 FASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMEIEKVKGFCQVVVASKVREGLAHLI 780

  Fly   739 QTIGLGGMKPNTVIIGWPYSWRQ-EGRNSWKTFIQTVRTVAACHMALMVPKGINFYPESNHK--I 800
            |:.|||||:.|:|::||||.||| |...:|||||.|||...|.|:||:|||.|.||| |||:  :
Human   781 QSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYP-SNHERYL 844

  Fly   801 GGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFTVAQIEDNSIQMKKDLKTFLYHLRIEAD 865
            .|:||:||||||||:||||||||:||:.||.|::|||||||::||||||||||..||||||:||:
Human   845 EGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQMDDNSIQMKKDLAVFLYHLRLEAE 909

  Fly   866 VEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIV 930
            ||||||:||||||||||||||||||:||||.:.|.|.|..:..|.:.|     ..:.:.|.....
Human   910 VEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTEREREAQLVKD-----RHSALRLESLYS 969

  Fly   931 DHHYDATKTASKVRFA---DPTIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKAD 992
            |...::...|.|::..   |..:.||.......|..|..:
Human   970 DEEDESAVGADKIQMTWTRDKYMTETWDPSHAPDNFRELV------------------------- 1009

  Fly   993 GDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTE 1057
                 .:|||:.||||||||:|||||||.:|.||:||::|:|||||  .:|.:.|||||||||||
Human  1010 -----HIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPR--NSEGDENYMEFLEVLTE 1067

  Fly  1058 GLEKVLMVRGGGREVITIYS 1077
            |||:||:|||||||||||||
Human  1068 GLERVLLVRGGGREVITIYS 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	592/1057 (56%)
kcc	NP_001286795.1	SLC12	674..1077	CDD:281515	220/408 (54%)
SLC12A4	NP_001139434.1	2a30	70..1087	CDD:273347	592/1054 (56%)
		SLC5-6-like_sbd	144..>305	CDD:294310	107/160 (67%)
		SLC12	711..1087	CDD:281515	220/413 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158234
Domainoid	1	1.000	426	1.000	Domainoid score	I605
eggNOG	1	0.900	-	-		E2759_KOG2082
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21056
Inparanoid	1	1.050	1162	1.000	Inparanoid score	I205
Isobase	1	0.950	-	0	Normalized mean entropy	S2108
OMA	1	1.010	-	-		QHG57166
OrthoDB	1	1.010	-	-		D110005at33208
OrthoFinder	1	1.000	-	-		FOG0000627
OrthoInspector	1	1.000	-	-		otm41076
orthoMCL	1	0.900	-	-		OOG6_101034
Panther	1	1.100	-	-	LDO	PTHR11827
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3041
SonicParanoid	1	1.000	-	-		X451
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750