DRSC/TRiP Functional Genomics Resources

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Protein Alignment kcc and SLC12A2

DIOPT Version :9

Sequence 1:NP_001286795.1 Gene:kcc / 37800 FlyBaseID:FBgn0261794 Length:1077 Species:Drosophila melanogaster
Sequence 2:NP_001037.1 Gene:SLC12A2 / 6558 HGNCID:10911 Length:1212 Species:Homo sapiens


Alignment Length:1169 Identity:308/1169 - (26%)
Similarity:487/1169 - (41%) Gaps:312/1169 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 HRAEENQKSSIDPNLYLYDDDLETRPHISTFISSIANYENTIPAATDPDAKPAAPS---ARMGTL 97
            |.|.:..:..:.|:|....|:||..|    |....||.|.:.| ..|......|.|   .:.|.:
Human   229 HTAAQLGEKLLRPSLAELHDELEKEP----FEDGFANGEESTP-TRDAVVTYTAESKGVVKFGWI 288

  Fly    98 IGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTCCCVTMLTAISMSAIATNGVVPAGGSY 162
            .||.:.|:.||:||:|||||:|:||.||.....|:::....||.:|.:|.|||||||.|..||:|
Human   289 KGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAY 353

  Fly   163 FMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVLTYMAPWASIFGDFTKDADAMYNNFRV 227
            ::||||||||||||:|::|.....:|.|||:||..|.|:..:...:.:..|       ..|:.|:
Human   354 YLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMID-------EINDIRI 411

  Fly   228 YGTLLLIFMGLIVFLGVKFVNKFATVALACVILSIIAVYVGIFDNIHGNEKLYMCVLGKRLLKDI 292
            .|.:.::.:..|...|:::..|...|.|..::|:|....:|.|                     |
Human   412 IGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTF---------------------I 455

  Fly   293 PLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVKGIKGLASGVFYDNIFPSFLEKGQFISYGKS 357
            |||:                           .|.||..|..|.:|.:|..|.|.|:..|.|    
Human   456 PLES---------------------------KKPKGFFGYKSEIFNENFGPDFREEETFFS---- 489

  Fly   358 AIDIENTSGESYNQIMADITTSFTLLIGIFFPSVTGIMAGSNRSGDLADAQKSIPIGTICAILTT 422
                                     :..||||:.|||:||:|.||||||.|.:||.||:.|||.|
Human   490 -------------------------VFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILIT 529

  Fly   423 STVYLSSVMFFAGTVDNLLLRDKFGQSIGGKLVV-----------------------ANIAWPNQ 464
            :.||:.    .|.:|.:.::||..| ::...:|.                       .:....|.
Human   530 TLVYVG----IAVSVGSCVVRDATG-NVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNN 589

  Fly   465 W-----------VILIGSFLSTLGAGLQSLTGAPRLLQAIARDEIIPFLAPFAKS-SKRGEPTRA 517
            :           :|..|.|.:||.:.|.||..||::.||:.:|.|.|....|||. .|..||.|.
Human   590 FQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRG 654

  Fly   518 LLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVNLACAVQTLLRTPNWRPRFKFYHWSLSLIG 582
            .:||.:|....||:..::::||::|.|||..|..:|.:....:|.::|.|||.||:|:..:||:|
Human   655 YILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLG 719

  Fly   583 LTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAEKEWGDGIRGMALTAARYSLLRLEEGPPHT 647
            ..||..||.:.:|:.||:...:.:.:|.|:.|:..:..||...:.:....|....:||.....|.
Human   720 AILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHV 784

  Fly   648 KNWRPQILVLSKLNDNLLPKYRKIFSFATQLKAGKGLTICVSVIKGDHTKITNKAVDAKATLRKY 712
            ||:|||.||::...::.......:..|...:    ||.||..|..|...:...:....:|..:::
Human   785 KNFRPQCLVMTGAPNSRPALLHLVHDFTKNV----GLMICGHVHMGPRRQAMKEMSIDQAKYQRW 845

  Fly   713 MTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMKPNTVIIGWPYSWRQEGRNSWKTFIQTVRTV 777
            :...|:|.|...:.|..:.||...::|..|||.|||||:::|:...|.|........:|......
Human   846 LIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDA 910

  Fly   778 AACHMALMVPK-------------------------------GINFYPESN-------------H 798
            ......::|.:                               .:.:..:|:             |
Human   911 FDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITH 975

  Fly   799 KI------------------------------------------GGN-IDIWWIVHDGGLLMLLP 820
            |:                                          |.| ||:||:..||||.:|:|
Human   976 KVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIP 1040

  Fly   821 FLLKQHRTWRNCKLRIFTVAQIEDNSIQM-KKDLKTFLYHLRIE-ADVEVVEMNNSDISAYTYER 883
            :||...:.|::||:|:|...:|  |.|.. ::.:.|.|...||: :|:.|:    .||:...   
Human  1041 YLLTTKKKWKDCKIRVFIGGKI--NRIDHDRRAMATLLSKFRIDFSDIMVL----GDINTKP--- 1096

  Fly   884 TLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNKMSLVQTIVDHHYDATKTASKVRFADP 948
                             ||||      |:.::|                                
Human  1097 -----------------KKEN------IIAFEE-------------------------------- 1106

  Fly   949 TIEETQHHDSQNDEKRNSIDLDGPENADTPETTSNKDESTEKADGDFKSSVKPDEFNVRRMHTAI 1013
            .||..:.|:   |:|...|       ||    ...:||.....|.:.       |....:.:..|
Human  1107 IIEPYRLHE---DDKEQDI-------AD----KMKEDEPWRITDNEL-------ELYKTKTYRQI 1150

  Fly  1014 KLNEVIVEKSQDAQLVIMNLPGPPREVRAERERNYMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
            :|||::.|.|..|.:::|:||...:  .|.....||.:||.|::.|..:|:|||..:.|:|.||
Human  1151 RLNELLKEHSSTANIIVMSLPVARK--GAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS 1212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kccNP_001286795.1 2a30 49..1077 CDD:273347 303/1154 (26%)
SLC12 674..1077 CDD:281515 102/491 (21%)
SLC12A2NP_001037.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..81
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..138
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..193
2a30 216..1212 CDD:273347 306/1167 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..989 2/26 (8%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158232
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2083
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG57166
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.750

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