Protein Alignment kcc and SLC12A1

DIOPT Version :9

• Sequence 1: NP_001286795.1
• Gene: kcc / 37800
• FlyBaseID: FBgn0261794
• Length: 1077
• Species: Drosophila melanogaster
• Sequence 2: NP_000329.2
• Gene: SLC12A1 / 6557
• HGNCID: 10910
• Length: 1099
• Species: Homo sapiens
• Alignment Length: 1269
• Identity: 316/1269 - (24%)
• Similarity: 507/1269 - (39%)
• Gaps: 393/1269 - (30%)

  Fly     2 QSNSAKDDSDEMEIIPSEHNGTVHETK------------NEDSGDIHRAEENQKSSIDPNLYLYD 54
            :|::|.||:.:    |..:..|....:            |::..| :..:..:.:..|.:.:.||
Human    31 ESSAAADDNTD----PPHYEETSFGDEAQKRLRISFRPGNQECYD-NFLQSGETAKTDASFHAYD 90

  Fly    55 DDLETRPHISTF-------ISSIANYENT--------------------------IPAATD---- 82
            ....|. ::.||       :..|..|.||                          .|::.|
Human    91 SHTNTY-YLQTFGHNTMDAVPKIEYYRNTGSISGPKVNRPSLLEIHEQLAKNVAVTPSSADRVAN 154

  Fly    83 PDAKPAAPSA-----------RMGTLIGVFLPCIQNIFGVILFIRLTWVVGTAGAVCGFLIVLTC 136
            .|..|....|           :.|.:.||.:.|:.||:||:|||||:|:||.||...|.||:|..
Human   155 GDGIPGDEQAENKEDDQAGVVKFGWVKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLS 219

  Fly   137 CCVTMLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGMLFYTGTTLAAAMYIVGAVEIVL 201
            ..||.:|.:|.|||||||.|..||:|::|||||||||||::|::|.....:|.|||:||..|.|:
Human   220 TMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVV 284

  Fly   202 TYMAPWASIFGDFTKDADAMY----NNFRVYGTLLLIFMGLIVFLGVKFVNKFATVALACVILSI 262
                       |..|::|:|.    |:.|:.|::.::.:..|...|:::..|...:.|..::::|
Human   285 -----------DLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 338

  Fly   263 IAVYVGIFDNIHGNEKLYMCVLGKRLLKDIPLENCTKEDSFLRDIYCPDGKCEEYYLANNVTKVK 327
            ...::|..                     ||                          :||..|.:
Human   339 ANFFIGTV---------------------IP--------------------------SNNEKKSR 356

  Fly   328 GIKGLASGVFYDNIFPSFLEKGQFISYGKSAIDIENTSGESYNQIMADITTSFTLLIGIFFPSVT 392
            |.....:.:|.:|..|.|                  |.||.:..:.|           ||||:.|
Human   357 GFFNYQASIFAENFGPRF------------------TKGEGFFSVFA-----------IFFPAAT 392

  Fly   393 GIMAGSNRSGDLADAQKSIPIGTICAILTTSTVYLSSVMFFAGTVDNLLLRDKFGQS----IGGK 453
            ||:||:|.||||.|.|.:||.||:.||..|:..||.    .|..|...::||..|..    |.|.
Human   393 GILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLG----VAICVGACVVRDATGNMNDTIISGM 453

  Fly   454 LVVANIAW------------PNQW-----------------VILIGSFLSTLGAGLQSLTGAPRL 489
            ....:.|.            |.|:                 :|..|.|.:||.:.|.||..||::
Human   454 NCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKV 518

  Fly   490 LQAIARDEIIPFLAPFAKS-SKRGEPTRALLLTIVICQCGILLGNVDLLAPLLSMFFLMCYGFVN 553
            .||:.:|.|...|..|||. .|..||.|..:||.:|....||:..::.:||::|.|||..|..:|
Human   519 FQALCKDNIYKALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALIN 583

  Fly   554 LACAVQTLLRTPNWRPRFKFYHWSLSLIGLTLCISVMIMTSWYFALIAMGMAIIIYKYIEYRGAE 618
            .:|...:..::|.|||.:..|:..:||.|..||.:||.:.:|:.|:|...:...:|.|:..:..:
Human   584 FSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFFLYVYVTCKKPD 648

  Fly   619 KEWGDGIRGMALTAARYSLLRLEEGPPHTKNWRPQILVLSKLNDNLLPKYR-KIFSFATQLKAGK 682
            ..||...:.::..:|..:.|.|.....|.||:|||.:||:.     .|..| .:...........
Human   649 VNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTG-----GPMTRPALLDITHAFTKNS 708

  Fly   683 GLTICVSVIKGDHTKITNKAVDAKATLRKYMTDEKVKGFCDVLVAQQIGEGLSSVIQTIGLGGMK 747
            ||.||..|..|.......:.....|..:.::...|:|.|...:.|....:|:.|::|..|||.||
Human   709 GLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 773

  Fly   748 PNTVIIGWPYSWRQEGRNSWKTFIQTVRTVAACHMALMV-------------------------- 786
            |||::||:..:||:......:.::..:.......:.:::
Human   774 PNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQGFDISQVLQVQEELERLEQER 838

  Fly   787 -----------------------------------PK---GIN-----FYPESNHKI-------- 800
                                               ||   .||     ...|.|.|:
Human   839 LALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFK 903

  Fly   801 ----GGNIDIWWIVHDGGLLMLLPFLLKQHRTWRNCKLRIFT---VAQIEDNSIQMKKDLKTFLY 858
                .|.||:||:..||||.:|:|::|...:.|::|||||:.   :.:||:..|.|...|..|
Human   904 KKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKF-- 966

  Fly   859 HLRIE-ADVEVVEMNNSDISAYTYERTLMMEQRNQMLRALGLNKKENSKVVQTIMDYKETPSDNK 922
              ||: ||:.::    .||:                :|.    .||:.||.:.:
Human   967 --RIKFADIHII----GDIN----------------IRP----NKESWKVFEEM----------- 994

  Fly   923 MSLVQTIVDHHYDATKTASKVRFADPTIEETQHHDSQND----EKRNSIDLDGPENADTPETTSN 983
                                       ||..:.|:|..|    ||   :..:.|......|..:.
Human   995 ---------------------------IEPYRLHESCKDLTTAEK---LKRETPWKITDAELEAV 1029

  Fly   984 KDESTEKADGDFKSSVKPDEFNVRRMHTAIKLNEVIVEKSQDAQLVIMNLPGPPREVRAERERN- 1047
            |::|                      :..::|||::.|.|:.|.|::::||       ..|:.:
Human  1030 KEKS----------------------YRQVRLNELLQEHSRAANLIVLSLP-------VARKGSI 1065

  Fly  1048 ----YMEFLEVLTEGLEKVLMVRGGGREVITIYS 1077
                ||.:||:||:.|..||:|||..:.|:|.||
Human  1066 SDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcc	NP_001286795.1	2a30	49..1077	CDD:273347	305/1208 (25%)
		SLC12	674..1077	CDD:281515	103/496 (21%)
SLC12A1	NP_000329.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..53		6/25 (24%)
		AA_permease_N	90..156	CDD:285588	10/66 (15%)
		2a30	104..1099	CDD:273347	300/1188 (25%)
		SLC12	694..1099	CDD:281515	104/502 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158243
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2083
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57166
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750